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10.1016/j.mam.2021.100996 http://scihub22266oqcxt.onion/10.1016/j.mam.2021.100996 34284874!8286244!34284874     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Aspects+Med 2021 ; 81 (ä): 100996 Nephropedia Template TP {{tp|p=34284874|t=2021. Neutrophils at the crossroads of acute viral infections and severity |pdf=|usr=}}{{34284874}} gab.com Text Neutrophils at the crossroads of acute viral infections and severity JO: Mol Aspects Med http://www.kidney.de/pget.php?&tw=1&pmid=34284874 #FOAvip Neutrophils are versatile immune effector cells essential for mounting a first-line defense against invading pathogens. However, uncontrolled activation can lead to severe life-threatening complications. Neutrophils exist as a heterogeneous population, and their interaction with pathogens and other immune cells may shape the outcome of the host immune response. Diverse classes of viruses, including the recently identified novel SARS-CoV-2, have shown to alter the various aspects of neutrophil biology, offering possibilities for selective intervention. Here, we review heterogeneity within the neutrophil population, highlighting the functional consequences of circulating phenotypes and their critical involvement in exaggerating protective and pathological immune responses against the viruses. We discuss the recent findings of neutrophil extracellular traps (NETs) in COVID-19 pathology and cover other viruses, where neutrophil biology and NETs are crucial for developing disease severity. In the end, we have also pointed out the areas where neutrophil-mediated responses can be finely tuned to outline opportunities for therapeutic manipulation in controlling inflammation against viral infection. Twit Text FOAVip Neutrophils at the crossroads of acute viral infections and severity ????Mol Aspects Med http://www.kidney.de/pget.php?&tw=1&pmid=34284874 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34284874 #FOAvip English Wikipedia <ref>{{Cite pmid|34284874}}</ref> Neutrophils at the crossroads of acute viral infections and severity #MMPMID34284874 Rawat S; Vrati S; Banerjee A Mol Aspects Med 2021[Oct]; 81 (ä): 100996 PMID34284874show ga Neutrophils are versatile immune effector cells essential for mounting a first-line defense against invading pathogens. However, uncontrolled activation can lead to severe life-threatening complications. Neutrophils exist as a heterogeneous population, and their interaction with pathogens and other immune cells may shape the outcome of the host immune response. Diverse classes of viruses, including the recently identified novel SARS-CoV-2, have shown to alter the various aspects of neutrophil biology, offering possibilities for selective intervention. Here, we review heterogeneity within the neutrophil population, highlighting the functional consequences of circulating phenotypes and their critical involvement in exaggerating protective and pathological immune responses against the viruses. We discuss the recent findings of neutrophil extracellular traps (NETs) in COVID-19 pathology and cover other viruses, where neutrophil biology and NETs are crucial for developing disease severity. In the end, we have also pointed out the areas where neutrophil-mediated responses can be finely tuned to outline opportunities for therapeutic manipulation in controlling inflammation against viral infection. |*COVID-19[MESH] |*Extracellular Traps[MESH] |Humans[MESH] |Inflammation[MESH] |Neutrophils[MESH]Neutrophils at the crossroads of acute viral infections and severity (epmc).pdf DeepDyve Pubget Overpricing