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Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Nat+Commun 2021 ; 12 (1): 4383 Nephropedia Template TP
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SARS-CoV-2 antibody dynamics and transmission from community-wide serological testing in the Italian municipality of Vo #MMPMID34282139
Dorigatti I; Lavezzo E; Manuto L; Ciavarella C; Pacenti M; Boldrin C; Cattai M; Saluzzo F; Franchin E; Del Vecchio C; Caldart F; Castelli G; Nicoletti M; Nieddu E; Salvadoretti E; Labella B; Fava L; Guglielmo S; Fascina M; Grazioli M; Alvisi G; Vanuzzo MC; Zupo T; Calandrin R; Lisi V; Rossi L; Castagliuolo I; Merigliano S; Unwin HJT; Plebani M; Padoan A; Brazzale AR; Toppo S; Ferguson NM; Donnelly CA; Crisanti A
Nat Commun 2021[Jul]; 12 (1): 4383 PMID34282139show ga
In February and March 2020, two mass swab testing campaigns were conducted in Vo', Italy. In May 2020, we tested 86% of the Vo' population with three immuno-assays detecting antibodies against the spike and nucleocapsid antigens, a neutralisation assay and Polymerase Chain Reaction (PCR). Subjects testing positive to PCR in February/March or a serological assay in May were tested again in November. Here we report on the results of the analysis of the May and November surveys. We estimate a seroprevalence of 3.5% (95% Credible Interval (CrI): 2.8-4.3%) in May. In November, 98.8% (95% Confidence Interval (CI): 93.7-100.0%) of sera which tested positive in May still reacted against at least one antigen; 18.6% (95% CI: 11.0-28.5%) showed an increase of antibody or neutralisation reactivity from May. Analysis of the serostatus of the members of 1,118 households indicates a 26.0% (95% CrI: 17.2-36.9%) Susceptible-Infectious Transmission Probability. Contact tracing had limited impact on epidemic suppression.