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10.1136/jitc-2021-002890 http://scihub22266oqcxt.onion/10.1136/jitc-2021-002890 34281989!8291304!34281989     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunother+Cancer 2021 ; 9 (7): ä Nephropedia Template TP {{tp|p=34281989|t=2021. Consensus disease definitions for neurologic immune-related adverse events of immune checkpoint inhibitors |pdf=|usr=}}{{34281989}} gab.com Text Consensus disease definitions for neurologic immune-related adverse events of immune checkpoint inhibitors JO: J Immunother Cancer http://www.kidney.de/pget.php?&tw=1&pmid=34281989 #FOAvip Expanding the US Food and Drug Administration-approved indications for immune checkpoint inhibitors in patients with cancer has resulted in therapeutic success and immune-related adverse events (irAEs). Neurologic irAEs (irAE-Ns) have an incidence of 1%-12% and a high fatality rate relative to other irAEs. Lack of standardized disease definitions and accurate phenotyping leads to syndrome misclassification and impedes development of evidence-based treatments and translational research. The objective of this study was to develop consensus guidance for an approach to irAE-Ns including disease definitions and severity grading. A working group of four neurologists drafted irAE-N consensus guidance and definitions, which were reviewed by the multidisciplinary Neuro irAE Disease Definition Panel including oncologists and irAE experts. A modified Delphi consensus process was used, with two rounds of anonymous ratings by panelists and two meetings to discuss areas of controversy. Panelists rated content for usability, appropriateness and accuracy on 9-point scales in electronic surveys and provided free text comments. Aggregated survey responses were incorporated into revised definitions. Consensus was based on numeric ratings using the RAND/University of California Los Angeles (UCLA) Appropriateness Method with prespecified definitions. 27 panelists from 15 academic medical centers voted on a total of 53 rating scales (6 general guidance, 24 central and 18 peripheral nervous system disease definition components, 3 severity criteria and 2 clinical trial adjudication statements); of these, 77% (41/53) received first round consensus. After revisions, all items received second round consensus. Consensus definitions were achieved for seven core disorders: irMeningitis, irEncephalitis, irDemyelinating disease, irVasculitis, irNeuropathy, irNeuromuscular junction disorders and irMyopathy. For each disorder, six descriptors of diagnostic components are used: disease subtype, diagnostic certainty, severity, autoantibody association, exacerbation of pre-existing disease or de novo presentation, and presence or absence of concurrent irAE(s). These disease definitions standardize irAE-N classification. Diagnostic certainty is not always directly linked to certainty to treat as an irAE-N (ie, one might treat events in the probable or possible category). Given consensus on accuracy and usability from a representative panel group, we anticipate that the definitions will be used broadly across clinical and research settings. Twit Text FOAVip Consensus disease definitions for neurologic immune-related adverse events of immune checkpoint inhibitors ????J Immunother Cancer http://www.kidney.de/pget.php?&tw=1&pmid=34281989 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34281989 #FOAvip English Wikipedia <ref>{{Cite pmid|34281989}}</ref> Consensus disease definitions for neurologic immune-related adverse events of immune checkpoint inhibitors #MMPMID34281989 Guidon AC; Burton LB; Chwalisz BK; Hillis J; Schaller TH; Amato AA; Betof Warner A; Brastianos PK; Cho TA; Clardy SL; Cohen JV; Dietrich J; Dougan M; Doughty CT; Dubey D; Gelfand JM; Guptill JT; Johnson DB; Juel VC; Kadish R; Kolb N; LeBoeuf NR; Linnoila J; Mammen AL; Martinez-Lage M; Mooradian MJ; Naidoo J; Neilan TG; Reardon DA; Rubin KM; Santomasso BD; Sullivan RJ; Wang N; Woodman K; Zubiri L; Louv WC; Reynolds KL J Immunother Cancer 2021[Jul]; 9 (7): ä PMID34281989show ga Expanding the US Food and Drug Administration-approved indications for immune checkpoint inhibitors in patients with cancer has resulted in therapeutic success and immune-related adverse events (irAEs). Neurologic irAEs (irAE-Ns) have an incidence of 1%-12% and a high fatality rate relative to other irAEs. Lack of standardized disease definitions and accurate phenotyping leads to syndrome misclassification and impedes development of evidence-based treatments and translational research. The objective of this study was to develop consensus guidance for an approach to irAE-Ns including disease definitions and severity grading. A working group of four neurologists drafted irAE-N consensus guidance and definitions, which were reviewed by the multidisciplinary Neuro irAE Disease Definition Panel including oncologists and irAE experts. A modified Delphi consensus process was used, with two rounds of anonymous ratings by panelists and two meetings to discuss areas of controversy. Panelists rated content for usability, appropriateness and accuracy on 9-point scales in electronic surveys and provided free text comments. Aggregated survey responses were incorporated into revised definitions. Consensus was based on numeric ratings using the RAND/University of California Los Angeles (UCLA) Appropriateness Method with prespecified definitions. 27 panelists from 15 academic medical centers voted on a total of 53 rating scales (6 general guidance, 24 central and 18 peripheral nervous system disease definition components, 3 severity criteria and 2 clinical trial adjudication statements); of these, 77% (41/53) received first round consensus. After revisions, all items received second round consensus. Consensus definitions were achieved for seven core disorders: irMeningitis, irEncephalitis, irDemyelinating disease, irVasculitis, irNeuropathy, irNeuromuscular junction disorders and irMyopathy. For each disorder, six descriptors of diagnostic components are used: disease subtype, diagnostic certainty, severity, autoantibody association, exacerbation of pre-existing disease or de novo presentation, and presence or absence of concurrent irAE(s). These disease definitions standardize irAE-N classification. Diagnostic certainty is not always directly linked to certainty to treat as an irAE-N (ie, one might treat events in the probable or possible category). Given consensus on accuracy and usability from a representative panel group, we anticipate that the definitions will be used broadly across clinical and research settings. |*Practice Guidelines as Topic[MESH] |Consensus[MESH] |Drug-Related Side Effects and Adverse Reactions/*diagnosis[MESH] |Humans[MESH] |Immune Checkpoint Inhibitors/*adverse effects[MESH] |Immunotherapy/*adverse effects[MESH] |Nervous System Diseases/chemically induced/*diagnosis/immunology[MESH] |Neurologists/statistics & numerical data[MESH] |Oncologists/statistics & numerical data[MESH]Consensus disease definitions for neurologic immune-related adverse ev(epmc).pdf DeepDyve Pubget Overpricing