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10.3390/ijms22137127 http://scihub22266oqcxt.onion/10.3390/ijms22137127 34281182!8269364!34281182     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2021 ; 22 (13): ä Nephropedia Template TP {{tp|p=34281182|t=2021. Molecular Mechanisms of Palmitic Acid Augmentation in COVID-19 Pathologies |pdf=|usr=}}{{34281182}} gab.com Text Molecular Mechanisms of Palmitic Acid Augmentation in COVID-19 Pathologies JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34281182 #FOAvip The coronavirus disease 2019 (COVID-19) pandemic has claimed over 2.7 million lives globally. Obesity has been associated with increased severity and mortality of COVID-19. However, the molecular mechanisms by which obesity exacerbates COVID-19 pathologies are not well-defined. The levels of free fatty acids (FFAs) are elevated in obese subjects. This study was therefore designed to examine how excess levels of different FFAs may affect the progression of COVID-19. Biological molecules associated with palmitic acid (PA) and COVID-19 were retrieved from QIAGEN Knowledge Base, and Ingenuity Pathway Analysis tools were used to analyze these datasets and explore the potential pathways affected by different FFAs. Our study found that one of the top 10 canonical pathways affected by PA was the coronavirus pathogenesis pathway, mediated by key inflammatory mediators, including PTGS2; cytokines, including IL1beta and IL6; chemokines, including CCL2 and CCL5; transcription factors, including NFkappaB; translation regulators, including EEF1A1; and apoptotic mediators, including BAX. In contrast, n-3 fatty acids may attenuate PA's activation of the coronavirus pathogenesis pathway by inhibiting the activity of such mediators as IL1beta, CCL2, PTGS2, and BAX. Furthermore, PA may modulate the expression of ACE2, the main cell surface receptor for the SARS-CoV-2 spike protein. Twit Text FOAVip Molecular Mechanisms of Palmitic Acid Augmentation in COVID-19 Pathologies ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34281182 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34281182 #FOAvip English Wikipedia <ref>{{Cite pmid|34281182}}</ref> Molecular Mechanisms of Palmitic Acid Augmentation in COVID-19 Pathologies #MMPMID34281182 Joshi C; Jadeja V; Zhou H Int J Mol Sci 2021[Jul]; 22 (13): ä PMID34281182show ga The coronavirus disease 2019 (COVID-19) pandemic has claimed over 2.7 million lives globally. Obesity has been associated with increased severity and mortality of COVID-19. However, the molecular mechanisms by which obesity exacerbates COVID-19 pathologies are not well-defined. The levels of free fatty acids (FFAs) are elevated in obese subjects. This study was therefore designed to examine how excess levels of different FFAs may affect the progression of COVID-19. Biological molecules associated with palmitic acid (PA) and COVID-19 were retrieved from QIAGEN Knowledge Base, and Ingenuity Pathway Analysis tools were used to analyze these datasets and explore the potential pathways affected by different FFAs. Our study found that one of the top 10 canonical pathways affected by PA was the coronavirus pathogenesis pathway, mediated by key inflammatory mediators, including PTGS2; cytokines, including IL1beta and IL6; chemokines, including CCL2 and CCL5; transcription factors, including NFkappaB; translation regulators, including EEF1A1; and apoptotic mediators, including BAX. In contrast, n-3 fatty acids may attenuate PA's activation of the coronavirus pathogenesis pathway by inhibiting the activity of such mediators as IL1beta, CCL2, PTGS2, and BAX. Furthermore, PA may modulate the expression of ACE2, the main cell surface receptor for the SARS-CoV-2 spike protein. |COVID-19/blood/epidemiology/*metabolism/pathology[MESH] |Chemokines/metabolism[MESH] |Computational Biology/methods[MESH] |Cytokines/metabolism[MESH] |Databases, Factual[MESH] |Fatty Acids, Nonesterified/blood/*metabolism[MESH] |Humans[MESH] |Inflammation Mediators/metabolism[MESH] |Obesity/*metabolism/pathology[MESH] |Palmitic Acid/*metabolism[MESH] |Pandemics[MESH]Molecular Mechanisms of Palmitic Acid Augmentation in COVID-19 Patholo(epmc).pdf DeepDyve Pubget Overpricing