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10.1089/omi.2021.0068 http://scihub22266oqcxt.onion/10.1089/omi.2021.0068 34280038!8377512!34280038     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       OMICS 2021 ; 25 (8): 475-483 Nephropedia Template TP {{tp|p=34280038|t=2021. Traces of SARS-CoV-2 RNA in Peripheral Blood Cells of Patients with COVID-19 |pdf=|usr=}}{{34280038}} gab.com Text Traces of SARS-CoV-2 RNA in Peripheral Blood Cells of Patients with COVID-19 JO: OMICS http://www.kidney.de/pget.php?&tw=1&pmid=34280038 #FOAvip The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third virus that caused coronavirus-related outbreaks over the past 20 years. The outbreak was first reported in December 2019 in Wuhan, China, but rapidly progressed into a pandemic of an unprecedented scale since the 1918 flu pandemic. Besides respiratory complications in patients with COVID-19, clinical characterization of severe infection cases showed several other comorbidities, including multiple organ failure, and septic shock. To better understand the systemic pathogenesis of COVID-19, we interrogated the virus's presence in the peripheral blood cells, which might provide a form of trafficking or hiding to the virus. By analyzing >2 billion sequence reads of high-throughput transcriptome sequence data from 180 samples of patients with active SARS-CoV-2 infection or healthy controls collected from 6 studies, we found evidence of traces of SARS-CoV-2 RNA in peripheral blood mononuclear cells in two samples from two independent studies. In contrast, the viral RNA was abundant in bronchoalveolar lavage specimens from the same patients. We also devised a "viral spike-to-actin" RNA normalization as a metric to compare across various samples and minimize errors caused by intersample variability in total human RNA abundance. Our observation suggests immune presentation and discounts the possibility of extensive viral infection of lymphocytes or monocytes. Twit Text FOAVip Traces of SARS-CoV-2 RNA in Peripheral Blood Cells of Patients with COVID-19 ????OMICS http://www.kidney.de/pget.php?&tw=1&pmid=34280038 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34280038 #FOAvip English Wikipedia <ref>{{Cite pmid|34280038}}</ref> Traces of SARS-CoV-2 RNA in Peripheral Blood Cells of Patients with COVID-19 #MMPMID34280038 Moustafa A; Khalel RS; Aziz RK OMICS 2021[Aug]; 25 (8): 475-483 PMID34280038show ga The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third virus that caused coronavirus-related outbreaks over the past 20 years. The outbreak was first reported in December 2019 in Wuhan, China, but rapidly progressed into a pandemic of an unprecedented scale since the 1918 flu pandemic. Besides respiratory complications in patients with COVID-19, clinical characterization of severe infection cases showed several other comorbidities, including multiple organ failure, and septic shock. To better understand the systemic pathogenesis of COVID-19, we interrogated the virus's presence in the peripheral blood cells, which might provide a form of trafficking or hiding to the virus. By analyzing >2 billion sequence reads of high-throughput transcriptome sequence data from 180 samples of patients with active SARS-CoV-2 infection or healthy controls collected from 6 studies, we found evidence of traces of SARS-CoV-2 RNA in peripheral blood mononuclear cells in two samples from two independent studies. In contrast, the viral RNA was abundant in bronchoalveolar lavage specimens from the same patients. We also devised a "viral spike-to-actin" RNA normalization as a metric to compare across various samples and minimize errors caused by intersample variability in total human RNA abundance. Our observation suggests immune presentation and discounts the possibility of extensive viral infection of lymphocytes or monocytes. |Bronchoalveolar Lavage Fluid/*virology[MESH] |COVID-19/pathology/*virology[MESH] |High-Throughput Nucleotide Sequencing[MESH] |Humans[MESH] |Leukocytes, Mononuclear/*virology[MESH] |Pandemics[MESH] |RNA, Viral/analysis[MESH]Traces of SARS-CoV-2 RNA in Peripheral Blood Cells of Patients with CO(epmc).pdf DeepDyve Pubget Overpricing