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10.1007/s13337-021-00704-4

http://scihub22266oqcxt.onion/10.1007/s13337-021-00704-4
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suck abstract from ncbi


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pmid34277894      Virusdisease 2021 ; 32 (3): 384-387
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  • A theoretical strategy for acceleration of human immune response against SARS-CoV-2: a fusion protein harboring virus-binding and pre-exposed antigen domains #MMPMID34277894
  • Rahmani R; Eivazi N; Paknejad M; Aminian M
  • Virusdisease 2021[Sep]; 32 (3): 384-387 PMID34277894show ga
  • Coronavirus disease 2019 (COVID-19) is a respiratory disease that outbreaks since December 2019 and spread globally. Various methods have been used to treat SARS-CoV-2 that is generally based on the information obtained from the therapeutic approaches used for SARS-COV and MERS patients. In this article, we introduce a theoretical strategy in which a two-domain fusion protein presents the virus to the immune system. This fusion protein contains a viral-binding domain such as the ACE2 domain and a domain such as the hepatitis B antigen that has previously been exposed to the immune system. This two-domain fusion protein, could be called "virus-presenting fusion protein", would attach to the virus spike protein via the ACE2 domain while the hepatitis B antigen would be bound by anti-hepatitis B antibodies facilitating the opsonization and presentation of the virus to the immune system. We believe that this virus-presenting fusion protein will accelerate the immune response to the SARS-CoV-2 virus.
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