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10.1039/d1sc00244a http://scihub22266oqcxt.onion/10.1039/d1sc00244a 34276947!8261716!34276947     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Chem+Sci 2021 ; 12 (26): 9168-9175 Nephropedia Template TP {{tp|p=34276947|t=2021. Determination of intermediate state structures in the opening pathway of SARS-CoV-2 spike using cryo-electron microscopy |pdf=|usr=}}{{34276947}} gab.com Text Determination of intermediate state structures in the opening pathway of SARS-CoV-2 spike using cryo-electron microscopy JO: Chem Sci http://www.kidney.de/pget.php?&tw=1&pmid=34276947 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19, a highly infectious disease that is severely affecting our society and welfare systems. In order to develop therapeutic interventions against this condition, one promising strategy is to target spike, the trimeric transmembrane glycoprotein that the virus uses to recognise and bind its host cells. Here we use a metainference cryo-electron microscopy approach to determine the opening pathway that brings spike from its inactive (closed) conformation to its active (open) one. The knowledge of the structures of the intermediate states of spike along this opening pathway enables us to identify a cryptic pocket that is not exposed in the open and closed states. These results underline the opportunities offered by the determination of the structures of the transient intermediate states populated during the dynamics of proteins to allow the therapeutic targeting of otherwise invisible cryptic binding sites. Twit Text FOAVip Determination of intermediate state structures in the opening pathway of SARS-CoV-2 spike using cryo-electron microscopy ????Chem Sci http://www.kidney.de/pget.php?&tw=1&pmid=34276947 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34276947 #FOAvip English Wikipedia <ref>{{Cite pmid|34276947}}</ref> Determination of intermediate state structures in the opening pathway of SARS-CoV-2 spike using cryo-electron microscopy #MMPMID34276947 Brotzakis ZF; Lohr T; Vendruscolo M Chem Sci 2021[Jul]; 12 (26): 9168-9175 PMID34276947show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19, a highly infectious disease that is severely affecting our society and welfare systems. In order to develop therapeutic interventions against this condition, one promising strategy is to target spike, the trimeric transmembrane glycoprotein that the virus uses to recognise and bind its host cells. Here we use a metainference cryo-electron microscopy approach to determine the opening pathway that brings spike from its inactive (closed) conformation to its active (open) one. The knowledge of the structures of the intermediate states of spike along this opening pathway enables us to identify a cryptic pocket that is not exposed in the open and closed states. These results underline the opportunities offered by the determination of the structures of the transient intermediate states populated during the dynamics of proteins to allow the therapeutic targeting of otherwise invisible cryptic binding sites. äDetermination of intermediate state structures in the opening pathway (epmc).pdf DeepDyve Pubget Overpricing