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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Sci+Rep 2021 ; 11 (1): 14604 Nephropedia Template TP
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Multidisciplinary assessment of the Abbott BinaxNOW SARS-CoV-2 point-of-care antigen test in the context of emerging viral variants and self-administration #MMPMID34272449
Frediani JK; Levy JM; Rao A; Bassit L; Figueroa J; Vos MB; Wood A; Jerris R; Van Leung-Pineda; Gonzalez MD; Rogers BB; Mavigner M; Schinazi RF; Schoof N; Waggoner JJ; Kempker RR; Rebolledo PA; O'Neal JW; Stone C; Chahroudi A; Morris CR; Suessmith A; Sullivan J; Farmer S; Foster A; Roback JD; Ramachandra T; Washington C; Le K; Cordero MC; Esper A; Nehl EJ; Wang YF; Tyburski EA; Martin GS; Lam WA
Sci Rep 2021[Jul]; 11 (1): 14604 PMID34272449show ga
While there has been significant progress in the development of rapid COVID-19 diagnostics, as the pandemic unfolds, new challenges have emerged, including whether these technologies can reliably detect the more infectious variants of concern and be viably deployed in non-clinical settings as "self-tests". Multidisciplinary evaluation of the Abbott BinaxNOW COVID-19 Ag Card (BinaxNOW, a widely used rapid antigen test, included limit of detection, variant detection, test performance across different age-groups, and usability with self/caregiver-administration. While BinaxNOW detected the highly infectious variants, B.1.1.7 (Alpha) first identified in the UK, B.1.351 (Beta) first identified in South Africa, P.1 (Gamma) first identified in Brazil, B.1.617.2 (Delta) first identified in India and B.1.2, a non-VOC, test sensitivity decreased with decreasing viral loads. Moreover, BinaxNOW sensitivity trended lower when devices were performed by patients/caregivers themselves compared to trained clinical staff, despite universally high usability assessments following self/caregiver-administration among different age groups. Overall, these data indicate that while BinaxNOW accurately detects the new viral variants, as rapid COVID-19 tests enter the home, their already lower sensitivities compared to RT-PCR may decrease even more due to user error.