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10.1038/s41467-021-24521-x http://scihub22266oqcxt.onion/10.1038/s41467-021-24521-x 34272374!8285531!34272374     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 4354 Nephropedia Template TP {{tp|p=34272374|t=2021. SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance |pdf=|usr=}}{{34272374}} gab.com Text SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34272374 #FOAvip Understanding how SARS-CoV-2 spreads within the respiratory tract is important to define the parameters controlling the severity of COVID-19. Here we examine the functional and structural consequences of SARS-CoV-2 infection in a reconstructed human bronchial epithelium model. SARS-CoV-2 replication causes a transient decrease in epithelial barrier function and disruption of tight junctions, though viral particle crossing remains limited. Rather, SARS-CoV-2 replication leads to a rapid loss of the ciliary layer, characterized at the ultrastructural level by axoneme loss and misorientation of remaining basal bodies. Downregulation of the master regulator of ciliogenesis Foxj1 occurs prior to extensive cilia loss, implicating this transcription factor in the dedifferentiation of ciliated cells. Motile cilia function is compromised by SARS-CoV-2 infection, as measured in a mucociliary clearance assay. Epithelial defense mechanisms, including basal cell mobilization and interferon-lambda induction, ramp up only after the initiation of cilia damage. Analysis of SARS-CoV-2 infection in Syrian hamsters further demonstrates the loss of motile cilia in vivo. This study identifies cilia damage as a pathogenic mechanism that could facilitate SARS-CoV-2 spread to the deeper lung parenchyma. Twit Text FOAVip SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34272374 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34272374 #FOAvip English Wikipedia <ref>{{Cite pmid|34272374}}</ref> SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance #MMPMID34272374 Robinot R; Hubert M; de Melo GD; Lazarini F; Bruel T; Smith N; Levallois S; Larrous F; Fernandes J; Gellenoncourt S; Rigaud S; Gorgette O; Thouvenot C; Trebeau C; Mallet A; Dumenil G; Gobaa S; Etournay R; Lledo PM; Lecuit M; Bourhy H; Duffy D; Michel V; Schwartz O; Chakrabarti LA Nat Commun 2021[Jul]; 12 (1): 4354 PMID34272374show ga Understanding how SARS-CoV-2 spreads within the respiratory tract is important to define the parameters controlling the severity of COVID-19. Here we examine the functional and structural consequences of SARS-CoV-2 infection in a reconstructed human bronchial epithelium model. SARS-CoV-2 replication causes a transient decrease in epithelial barrier function and disruption of tight junctions, though viral particle crossing remains limited. Rather, SARS-CoV-2 replication leads to a rapid loss of the ciliary layer, characterized at the ultrastructural level by axoneme loss and misorientation of remaining basal bodies. Downregulation of the master regulator of ciliogenesis Foxj1 occurs prior to extensive cilia loss, implicating this transcription factor in the dedifferentiation of ciliated cells. Motile cilia function is compromised by SARS-CoV-2 infection, as measured in a mucociliary clearance assay. Epithelial defense mechanisms, including basal cell mobilization and interferon-lambda induction, ramp up only after the initiation of cilia damage. Analysis of SARS-CoV-2 infection in Syrian hamsters further demonstrates the loss of motile cilia in vivo. This study identifies cilia damage as a pathogenic mechanism that could facilitate SARS-CoV-2 spread to the deeper lung parenchyma. |*SARS-CoV-2[MESH] |Animals[MESH] |Axoneme[MESH] |Basal Bodies[MESH] |COVID-19/*pathology[MESH] |Cilia/metabolism/pathology/*ultrastructure[MESH] |Cricetinae[MESH] |Cytokines[MESH] |Epithelial Cells/pathology[MESH] |Forkhead Transcription Factors/metabolism[MESH] |Humans[MESH] |Lung/pathology[MESH] |Male[MESH] |Mesocricetus[MESH] |Mucociliary Clearance/*physiology[MESH] |Respiratory Mucosa/metabolism/pathology[MESH]SARS-CoV-2 infection induces the dedifferentiation of multiciliated ce(epmc).pdf DeepDyve Pubget Overpricing