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10.2967/jnumed.121.262296

http://scihub22266oqcxt.onion/10.2967/jnumed.121.262296
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34272318!8805777!34272318
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suck abstract from ncbi


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pmid34272318      J+Nucl+Med 2022 ; 63 (2): 270-273
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  • Evolution of (18)F-FDG PET/CT Findings in Patients After COVID-19: An Initial Investigation #MMPMID34272318
  • Thornton A; Fraioli F; Wan S; Garthwaite HS; Ganeshan B; Shortman RI; Endozo R; Voo S; Kayani I; Neriman D; Menezes L; Bomanji J; Hilllman T; Heightman M; Porter JC; Groves AM
  • J Nucl Med 2022[Feb]; 63 (2): 270-273 PMID34272318show ga
  • The aim of this study was to assess the temporal evolution of pulmonary (18)F-FDG uptake in patients with coronavirus disease 2019 (COVID-19) and post-COVID-19 lung disease (PCLD). Methods: Using our hospital's clinical electronic records, we retrospectively identified 23 acute COVID-19, 18 PCLD, and 9 completely recovered (18)F-FDG PET/CT patients during the 2 peaks of the U.K. pandemic. Pulmonary (18)F-FDG uptake was measured as a lung target-to-background ratio (TBR(lung) = SUV(max)/SUV(min)) and compared with temporal stage. Results: In acute COVID-19, less than 3 wk after infection, TBR(lung) was strongly correlated with time after infection (r(s) = 0.81, P < 0.001) and was significantly higher in the late stage than in the early stage (P = 0.001). In PCLD, TBR(lung) was lower in patients treated with high-dose steroids (P = 0.003) and in asymptomatic patients (P < 0.001). Conclusion: Pulmonary (18)F-FDG uptake in COVID-19 increases with time after infection. In PCLD, pulmonary (18)F-FDG uptake rises despite viral clearance, suggesting ongoing inflammation. There was lower pulmonary (18)F-FDG uptake in PCLD patients treated with steroids.
  • |*SARS-CoV-2[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19/*diagnostic imaging[MESH]
  • |Female[MESH]
  • |Fluorodeoxyglucose F18/*pharmacokinetics[MESH]
  • |Humans[MESH]
  • |Lung/*diagnostic imaging[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Positron Emission Tomography Computed Tomography/*methods[MESH]
  • |Radiopharmaceuticals/*pharmacokinetics[MESH]
  • |Retrospective Studies[MESH]


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