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10.1016/j.bj.2021.07.003 http://scihub22266oqcxt.onion/10.1016/j.bj.2021.07.003 34271250!8275844!34271250     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+J 2021 ; 44 (5): 570-581 Nephropedia Template TP {{tp|p=34271250|t=2021. Emerging mutation in SARS-CoV-2 spike: Widening distribution over time in different geographic areas |pdf=|usr=}}{{34271250}} gab.com Text Emerging mutation in SARS-CoV-2 spike: Widening distribution over time in different geographic areas JO: Biomed J http://www.kidney.de/pget.php?&tw=1&pmid=34271250 #FOAvip BACKGROUND: Recently, differences in mortality rates of COVID-19 in different geographic areas have become an important subject of research because these different mortality rates appear to be associated with mutations that appeared in SARS-CoV-2. The part of the viral body called the spike protein plays a critical role in the viral attachment and entry of the virus into the host cell. Accordingly, we hypothesized that mutations in this area will affect viral infectivity. METHODS: A total of 193 sequences of spike SARS-CoV-2 were randomly retrieved from five different geographic areas and collection dates (from December 2019 until July 2020). Multiple sequence alignment for mutation and phylogenetic analyses was conducted using Bioedit, UniProt, and MEGA X. RESULTS: We found 169 total mutations with 37 different mutations across the included samples. The D614G is the first and most frequently established mutation in different regions including Europe, Asia, America, Africa and Australia with the number of mutations of 49, 33, 17, 16 and 4, respectively. Furthermore, we also found mutations in several important domains in this virus including NTD and CTR/RBD of S1 subunit and at S2 subunit area, namely the peptide fusion (FP), and both heptad repetition (HR1 and 2) domains that suggested this could influence virus binding and virus-host cell membrane fusion. CONCLUSION: In summary, we concluded that mutation had generated diversity of spike SARS-CoV-2 sequences worldwide and is still growing. This analysis may provide important evidence that should be considered in vaccine development in different geographic areas. Twit Text FOAVip Emerging mutation in SARS-CoV-2 spike: Widening distribution over time in different geographic areas ????Biomed J http://www.kidney.de/pget.php?&tw=1&pmid=34271250 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34271250 #FOAvip English Wikipedia <ref>{{Cite pmid|34271250}}</ref> Emerging mutation in SARS-CoV-2 spike: Widening distribution over time in different geographic areas #MMPMID34271250 Ysrafil Y; Mus R; Gama NI; Rahmaisyah D; Nur'amalia R Biomed J 2021[Oct]; 44 (5): 570-581 PMID34271250show ga BACKGROUND: Recently, differences in mortality rates of COVID-19 in different geographic areas have become an important subject of research because these different mortality rates appear to be associated with mutations that appeared in SARS-CoV-2. The part of the viral body called the spike protein plays a critical role in the viral attachment and entry of the virus into the host cell. Accordingly, we hypothesized that mutations in this area will affect viral infectivity. METHODS: A total of 193 sequences of spike SARS-CoV-2 were randomly retrieved from five different geographic areas and collection dates (from December 2019 until July 2020). Multiple sequence alignment for mutation and phylogenetic analyses was conducted using Bioedit, UniProt, and MEGA X. RESULTS: We found 169 total mutations with 37 different mutations across the included samples. The D614G is the first and most frequently established mutation in different regions including Europe, Asia, America, Africa and Australia with the number of mutations of 49, 33, 17, 16 and 4, respectively. Furthermore, we also found mutations in several important domains in this virus including NTD and CTR/RBD of S1 subunit and at S2 subunit area, namely the peptide fusion (FP), and both heptad repetition (HR1 and 2) domains that suggested this could influence virus binding and virus-host cell membrane fusion. CONCLUSION: In summary, we concluded that mutation had generated diversity of spike SARS-CoV-2 sequences worldwide and is still growing. This analysis may provide important evidence that should be considered in vaccine development in different geographic areas. |*COVID-19[MESH] |*SARS-CoV-2[MESH] |Humans[MESH] |Mutation/genetics[MESH] |Phylogeny[MESH]Emerging mutation in SARS-CoV-2 spike: Widening distribution over time(epmc).pdf DeepDyve Pubget Overpricing