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10.1016/j.ijid.2021.07.027 http://scihub22266oqcxt.onion/10.1016/j.ijid.2021.07.027 34271199!8276555!34271199     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Infect+Dis 2021 ; 109 (ä): 304-309 Nephropedia Template TP {{tp|p=34271199|t=2021. Age significantly influences the sensitivity of SARS-CoV-2 rapid antibody assays |pdf=|usr=}}{{34271199}} gab.com Text Age significantly influences the sensitivity of SARS-CoV-2 rapid antibody assays JO: Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=34271199 #FOAvip BACKGROUND: Point-of-care serological assays are a promising tool in COVID-19 diagnostics but do have limitations. Our study evaluated the sensitivity of five rapid antibody assays and explored factors influencing their sensitivity in detecting SARS-CoV-2-specific IgG and IgM antibodies. METHODS: Finger-prick blood samples from 102 participants, within 2-6 weeks of PCR-confirmed COVID-19 diagnosis, were tested for IgG and IgM using five rapid serological assays. The assay sensitivities were compared, and patient factors evaluated in order to investigate potential associations with assay sensitivity. RESULTS: Sensitivity ranged from 36% to 69% for IgG and 13% to 67% for IgM. Age was the only factor significantly influencing the likelihood of a detectable IgG or IgM response. Individuals aged 40 years and older had an increased likelihood of a detectable IgG or IgM antibody response by rapid antibody assay. CONCLUSION: Rapid serological assays demonstrate significant variability when used in a real-world clinical context. There may be limitations in their use for COVID-19 diagnosis among the young. Twit Text FOAVip Age significantly influences the sensitivity of SARS-CoV-2 rapid antibody assays ????Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=34271199 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34271199 #FOAvip English Wikipedia <ref>{{Cite pmid|34271199}}</ref> Age significantly influences the sensitivity of SARS-CoV-2 rapid antibody assays #MMPMID34271199 Irwin N; Murray L; Ozynski B; Richards GA; Paget G; Venturas J; Kalla I; Diana N; Mahomed A; Zamparini J Int J Infect Dis 2021[Aug]; 109 (ä): 304-309 PMID34271199show ga BACKGROUND: Point-of-care serological assays are a promising tool in COVID-19 diagnostics but do have limitations. Our study evaluated the sensitivity of five rapid antibody assays and explored factors influencing their sensitivity in detecting SARS-CoV-2-specific IgG and IgM antibodies. METHODS: Finger-prick blood samples from 102 participants, within 2-6 weeks of PCR-confirmed COVID-19 diagnosis, were tested for IgG and IgM using five rapid serological assays. The assay sensitivities were compared, and patient factors evaluated in order to investigate potential associations with assay sensitivity. RESULTS: Sensitivity ranged from 36% to 69% for IgG and 13% to 67% for IgM. Age was the only factor significantly influencing the likelihood of a detectable IgG or IgM response. Individuals aged 40 years and older had an increased likelihood of a detectable IgG or IgM antibody response by rapid antibody assay. CONCLUSION: Rapid serological assays demonstrate significant variability when used in a real-world clinical context. There may be limitations in their use for COVID-19 diagnosis among the young. |*COVID-19[MESH] |*SARS-CoV-2[MESH] |Adult[MESH] |Antibodies, Viral[MESH] |COVID-19 Testing[MESH] |Humans[MESH] |Immunoglobulin M[MESH] |Middle Aged[MESH]Age significantly influences the sensitivity of SARS-CoV-2 rapid antib(epmc).pdf DeepDyve Pubget Overpricing