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10.1016/j.jnutbio.2021.108821 http://scihub22266oqcxt.onion/10.1016/j.jnutbio.2021.108821 34271099!8277543!34271099     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34271099&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Nutr+Biochem 2021 ; 98 (?): 108821 Nephropedia Template TP {{tp|p=34271099|t=2021. Gut probiotic Lactobacillus rhamnosus attenuates PDE4B-mediated interleukin-6 induced by SARS-CoV-2 membrane glycoprotein |pdf=|usr=}}{{34271099}} gab.com Text Gut probiotic Lactobacillus rhamnosus attenuates PDE4B-mediated interleukin-6 induced by SARS-CoV-2 membrane glycoprotein JO: J Nutr Biochem http://www.kidney.de/pget.php?&tw=1&pmid=34271099 #FOAvip Membrane glycoprotein is the most abundant protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but its role in coronavirus disease 2019 (COVID-19) has not been fully characterized. Mice intranasally inoculated with membrane glycoprotein substantially increased the interleukin (IL)-6, a hallmark of the cytokine storm, in bronchoalveolar lavage fluid (BALF), compared to mice inoculated with green fluorescent protein (GFP). The high level of IL-6 induced by membrane glycoprotein was significantly diminished in phosphodiesterase 4 (PDE4B) knockout mice, demonstrating the essential role of PDE4B in IL-6 signaling. Mycelium fermentation of Lactobacillus rhamnosus (L. rhamnosus) EH8 strain yielded butyric acid, which can down-regulate the PDE4B expression and IL-6 secretion in macrophages. Feeding mice with mycelia increased the relative abundance of commensal L. rhamnosus. Two-week supplementation of mice with L. rhamnosus plus mycelia considerably decreased membrane glycoprotein-induced PDE4B expression and IL-6 secretion. The probiotic activity of L. rhamnosus plus mycelia against membrane glycoprotein was abolished in mice treated with GLPG-0974, an antagonist of free fatty acid receptor 2 (Ffar2). Activation of Ffar2 in the gut-lung axis for down-regulation of the PDE4B-IL-6 signalling may provide targets for development of modalities including probiotics for treatment of the cytokine storm in COVID-19. Twit Text FOAVip Gut probiotic Lactobacillus rhamnosus attenuates PDE4B-mediated interleukin-6 induced by SARS-CoV-2 membrane glycoprotein ????J Nutr Biochem http://www.kidney.de/pget.php?&tw=1&pmid=34271099 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34271099 #FOAvip English Wikipedia <ref>{{Cite pmid|34271099}}</ref> Gut probiotic Lactobacillus rhamnosus attenuates PDE4B-mediated interleukin-6 induced by SARS-CoV-2 membrane glycoprotein #MMPMID34271099 Pham MT; Yang AJ; Kao MS; Gankhuyag U; Zayabaatar E; Jin SC; Huang CM J Nutr Biochem 2021[Dec]; 98 (?): 108821 PMID34271099show ga Membrane glycoprotein is the most abundant protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but its role in coronavirus disease 2019 (COVID-19) has not been fully characterized. Mice intranasally inoculated with membrane glycoprotein substantially increased the interleukin (IL)-6, a hallmark of the cytokine storm, in bronchoalveolar lavage fluid (BALF), compared to mice inoculated with green fluorescent protein (GFP). The high level of IL-6 induced by membrane glycoprotein was significantly diminished in phosphodiesterase 4 (PDE4B) knockout mice, demonstrating the essential role of PDE4B in IL-6 signaling. Mycelium fermentation of Lactobacillus rhamnosus (L. rhamnosus) EH8 strain yielded butyric acid, which can down-regulate the PDE4B expression and IL-6 secretion in macrophages. Feeding mice with mycelia increased the relative abundance of commensal L. rhamnosus. Two-week supplementation of mice with L. rhamnosus plus mycelia considerably decreased membrane glycoprotein-induced PDE4B expression and IL-6 secretion. The probiotic activity of L. rhamnosus plus mycelia against membrane glycoprotein was abolished in mice treated with GLPG-0974, an antagonist of free fatty acid receptor 2 (Ffar2). Activation of Ffar2 in the gut-lung axis for down-regulation of the PDE4B-IL-6 signalling may provide targets for development of modalities including probiotics for treatment of the cytokine storm in COVID-19. |Animals[MESH] |Butyric Acid[MESH] |Cell Line[MESH] |Cloning, Molecular[MESH] |Coronavirus M Proteins/*pharmacology[MESH] |Cyclic Nucleotide Phosphodiesterases, Type 4/genetics/*metabolism[MESH] |Female[MESH] |Fermentation[MESH] |Gene Expression Regulation/drug effects[MESH] |Humans[MESH] |Interleukin-6/genetics/*metabolism[MESH] |Lacticaseibacillus rhamnosus/*physiology[MESH] |Mice[MESH] |Mice, Inbred ICR[MESH] |Probiotics/*pharmacology[MESH] |Receptors, G-Protein-Coupled/metabolism[MESH]Gut probiotic Lactobacillus rhamnosus attenuates PDE4B-mediated interl(epmc).pdf DeepDyve Pubget Overpricing