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10.3389/fnagi.2021.698184

http://scihub22266oqcxt.onion/10.3389/fnagi.2021.698184
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suck abstract from ncbi


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pmid34267649      Front+Aging+Neurosci 2021 ; 13 (ä): 698184
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  • Dementia as Risk Factor for Severe Coronavirus Disease 2019: A Case-Control Study #MMPMID34267649
  • Pisaturo M; Calo F; Russo A; Camaioni C; Giaccone A; Pinchera B; Gentile I; Simeone F; Iodice A; Maggi P; Coppola N
  • Front Aging Neurosci 2021[]; 13 (ä): 698184 PMID34267649show ga
  • BACKGROUND: The aim of the present study was to investigate the outcome of patients with SARS-CoV-2 infection and dementia. PATIENTS AND METHODS: In a multicenter, observational, 1:2 matched case-control study all 23 patients with a history of dementia, hospitalized with a diagnosis of SARS-CoV-2 infection from February 28th 2020 to January 31st 2021 were enrolled. For each Case, 2 patients without dementia observed in the same period study, pair matched for gender, age (+/-5 years), PaO(2)/FiO(2) (P/F) ratio at admission (<200, or >200), number of comorbidities (+/-1; excluding dementia) were chosen (Control group). RESULTS: The majority of patients were males (60.9% of Cases and Controls) and very elderly [median age 82 years (IQR: 75.5-85) in the Cases and 80 (IQR: 75.5-83.75) in the Controls]. The prevalence of co-pathologies was very high: all the Cases and 43 (93.5%) Controls showed a Charlson comorbidity index of at least 2. During hospitalization the patients in the Case group less frequently had a moderate disease of COVID-19 (35 vs. 67.4%, p = 0.02), more frequently a severe disease (48 vs. 22%, p = 0.03) and more frequently died (48 vs. 22%, p = 0.03). Moreover, during coronavirus disease 2019 (COVID-19), 14 (60.8%) patients in the Case group and 1 (2.1%; p < 0.000) in the Control group showed signs and symptoms of delirium. CONCLUSION: Patients with dementia are vulnerable and have an increased risk of a severe disease and death when infected with COVID-19.
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