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10.1186/s12879-021-06378-z

http://scihub22266oqcxt.onion/10.1186/s12879-021-06378-z
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34266396!8282405!34266396
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suck abstract from ncbi


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pmid34266396      BMC+Infect+Dis 2021 ; 21 (1): 685
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  • High risk groups for severe COVID-19 in a whole of population cohort in Australia #MMPMID34266396
  • Liu B; Spokes P; He W; Kaldor J
  • BMC Infect Dis 2021[Jul]; 21 (1): 685 PMID34266396show ga
  • BACKGROUND: Increasing age is the strongest known risk factor for severe COVID-19 disease but information on other factors is more limited. METHODS: All cases of COVID-19 diagnosed from January-October 2020 in New South Wales Australia were followed for COVID-19-related hospitalisations, intensive care unit (ICU) admissions and deaths through record linkage. Adjusted hazard ratios (aHR) for severe COVID-19 disease, measured by hospitalisation or death, or very severe COVID-19, measured by ICU admission or death according to age, sex, socioeconomic status and co-morbidities were estimated. RESULTS: Of 4054 confirmed cases, 468 (11.5%) were classified as having severe COVID-19 and 190 (4.7%) as having very severe disease. After adjusting for sex, socioeconomic status and comorbidities, increasing age led to the greatest risk of very severe disease. Compared to those 30-39 years, the aHR for ICU or death from COVID-19 was 4.45 in those 70-79 years; 8.43 in those 80-89 years; 16.19 in those 90+ years. After age, relative risks for very severe disease associated with other factors were more moderate: males vs females aHR 1.40 (95%CI 1.04-1.88); immunosuppressive conditions vs none aHR 2.20 (1.35-3.57); diabetes vs none aHR 1.88 (1.33-2.67); chronic lung disease vs none aHR 1.68 (1.18-2.38); obesity vs not obese aHR 1.52 (1.05-2.21). More comorbidities was associated with significantly greater risk; comparing those with 3+ comorbidities to those with none, aHR 5.34 (3.15-9.04). CONCLUSIONS: In a setting with high COVID-19 case ascertainment and almost complete case follow-up, we found the risk of very severe disease varies by age, sex and presence of comorbidities. This variation should be considered in targeting prevention strategies.
  • |*Aging[MESH]
  • |*Intensive Care Units[MESH]
  • |*Sex Characteristics[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19/*diagnosis/*epidemiology/mortality/virology[MESH]
  • |Cohort Studies[MESH]
  • |Comorbidity[MESH]
  • |Female[MESH]
  • |Hospitalization/*statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |New South Wales/epidemiology[MESH]
  • |Proportional Hazards Models[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2/pathogenicity[MESH]


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