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10.1016/j.coi.2021.06.013 http://scihub22266oqcxt.onion/10.1016/j.coi.2021.06.013 34265589!8452259!34265589     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Immunol 2021 ; 72 (ä): 230-238 Nephropedia Template TP {{tp|p=34265589|t=2021. Monogenic autoimmunity and infectious diseases: the double-edged sword of immune dysregulation |pdf=|usr=}}{{34265589}} gab.com Text Monogenic autoimmunity and infectious diseases: the double-edged sword of immune dysregulation JO: Curr Opin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34265589 #FOAvip The study of monogenic autoimmune diseases has provided key insights into molecular mechanisms involved in development of autoimmunity and immune tolerance. It has also become clear that such inborn errors of immunity (IEIs) frequently present clinically not only with autoimmune diseases, but also frequently have increased susceptibility to infection. The genes associated with monogenic autoimmunity influence diverse functional pathways, and the resulting immune dysregulation also impacts the complex and coordinated immune response to pathogens, for example type I interferon and cytokine signaling, the complement pathway and proper differentiation of the immune response. The SARS-CoV-2 pandemic has highlighted how monogenic autoimmunity can increase risk for serious infection with the discovery of severe disease in patients with pre-existing antibodies to Type I IFNs. This review discusses recent insight into the relationship between monogenic autoimmunity and infectious diseases. Twit Text FOAVip Monogenic autoimmunity and infectious diseases: the double-edged sword of immune dysregulation ????Curr Opin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34265589 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34265589 #FOAvip English Wikipedia <ref>{{Cite pmid|34265589}}</ref> Monogenic autoimmunity and infectious diseases: the double-edged sword of immune dysregulation #MMPMID34265589 Bigley TM; Cooper MA Curr Opin Immunol 2021[Oct]; 72 (ä): 230-238 PMID34265589show ga The study of monogenic autoimmune diseases has provided key insights into molecular mechanisms involved in development of autoimmunity and immune tolerance. It has also become clear that such inborn errors of immunity (IEIs) frequently present clinically not only with autoimmune diseases, but also frequently have increased susceptibility to infection. The genes associated with monogenic autoimmunity influence diverse functional pathways, and the resulting immune dysregulation also impacts the complex and coordinated immune response to pathogens, for example type I interferon and cytokine signaling, the complement pathway and proper differentiation of the immune response. The SARS-CoV-2 pandemic has highlighted how monogenic autoimmunity can increase risk for serious infection with the discovery of severe disease in patients with pre-existing antibodies to Type I IFNs. This review discusses recent insight into the relationship between monogenic autoimmunity and infectious diseases. |Animals[MESH] |Autoimmune Diseases/genetics/*immunology[MESH] |COVID-19/genetics/*immunology[MESH] |Communicable Diseases/genetics/*immunology[MESH] |Disease Susceptibility[MESH] |Humans[MESH] |Interferon Type I/metabolism[MESH]Monogenic autoimmunity and infectious diseases: the double-edged sword(epmc).pdf DeepDyve Pubget Overpricing