Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.cell.2021.06.029 http://scihub22266oqcxt.onion/10.1016/j.cell.2021.06.029 34265281!8241654!34265281     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34265281&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Cell 2021 ; 184 (17): 4401-4413.e10 Nephropedia Template TP {{tp|p=34265281|t=2021. Structure-guided T cell vaccine design for SARS-CoV-2 variants and sarbecoviruses |pdf=|usr=}}{{34265281}} gab.com Text Structure-guided T cell vaccine design for SARS-CoV-2 variants and sarbecoviruses JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=34265281 #FOAvip The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants that escape convalescent and vaccine-induced antibody responses has renewed focus on the development of broadly protective T-cell-based vaccines. Here, we apply structure-based network analysis and assessments of HLA class I peptide stability to define mutationally constrained CD8(+) T cell epitopes across the SARS-CoV-2 proteome. Highly networked residues are conserved temporally among circulating variants and sarbecoviruses and disproportionately impair spike pseudotyped lentivirus infectivity when mutated. Evaluation of HLA class I stabilizing activity for 18 globally prevalent alleles identifies CD8(+) T cell epitopes within highly networked regions with limited mutational frequencies in circulating SARS-CoV-2 variants and deep-sequenced primary isolates. Moreover, these epitopes elicit demonstrable CD8(+) T cell reactivity in convalescent individuals but reduced recognition in recipients of mRNA-based vaccines. These data thereby elucidate key mutationally constrained regions and immunogenic epitopes in the SARS-CoV-2 proteome for a global T-cell-based vaccine against emerging variants and SARS-like coronaviruses. Twit Text FOAVip Structure-guided T cell vaccine design for SARS-CoV-2 variants and sarbecoviruses ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=34265281 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34265281 #FOAvip English Wikipedia <ref>{{Cite pmid|34265281}}</ref> Structure-guided T cell vaccine design for SARS-CoV-2 variants and sarbecoviruses #MMPMID34265281 Nathan A; Rossin EJ; Kaseke C; Park RJ; Khatri A; Koundakjian D; Urbach JM; Singh NK; Bashirova A; Tano-Menka R; Senjobe F; Waring MT; Piechocka-Trocha A; Garcia-Beltran WF; Iafrate AJ; Naranbhai V; Carrington M; Walker BD; Gaiha GD Cell 2021[Aug]; 184 (17): 4401-4413.e10 PMID34265281show ga The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants that escape convalescent and vaccine-induced antibody responses has renewed focus on the development of broadly protective T-cell-based vaccines. Here, we apply structure-based network analysis and assessments of HLA class I peptide stability to define mutationally constrained CD8(+) T cell epitopes across the SARS-CoV-2 proteome. Highly networked residues are conserved temporally among circulating variants and sarbecoviruses and disproportionately impair spike pseudotyped lentivirus infectivity when mutated. Evaluation of HLA class I stabilizing activity for 18 globally prevalent alleles identifies CD8(+) T cell epitopes within highly networked regions with limited mutational frequencies in circulating SARS-CoV-2 variants and deep-sequenced primary isolates. Moreover, these epitopes elicit demonstrable CD8(+) T cell reactivity in convalescent individuals but reduced recognition in recipients of mRNA-based vaccines. These data thereby elucidate key mutationally constrained regions and immunogenic epitopes in the SARS-CoV-2 proteome for a global T-cell-based vaccine against emerging variants and SARS-like coronaviruses. |*Epitopes, T-Lymphocyte[MESH] |CD8-Positive T-Lymphocytes/immunology[MESH] |COVID-19 Vaccines/chemistry/*immunology[MESH] |COVID-19/immunology/prevention & control[MESH] |HLA Antigens/immunology[MESH] |Humans[MESH] |SARS-CoV-2/genetics/immunology[MESH]Structure-guided T cell vaccine design for SARS-CoV-2 variants and sa(epmc).pdf DeepDyve Pubget Overpricing