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10.1002/ppul.25549

http://scihub22266oqcxt.onion/10.1002/ppul.25549
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34265172!8441878!34265172
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suck abstract from ncbi


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pmid34265172      Pediatr+Pulmonol 2021 ; 56 (9): 2803-2810
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  • Oxidant and antioxidant balance in patients with COVID-19 #MMPMID34265172
  • Aykac K; Ozsurekci Y; Yayla BCC; Gurlevik SL; Oygar PD; Bolu NB; Tasar MA; Erdinc FS; Ertem GT; Neselioglu S; Erel O; Cengiz AB; Ceyhan M
  • Pediatr Pulmonol 2021[Sep]; 56 (9): 2803-2810 PMID34265172show ga
  • BACKGROUND: A crucial balance exists between oxidant and antioxidant mechanisms in the functional immune system. We aimed to evaluate the contributions of balance between these systems to coronavirus disease 2019 (COVID-19), a devastating pandemic caused by viral infection. METHOD: We analyzed serum oxidant and antioxidant stress parameters according to the clinical and demographic characteristics of children and adults with COVID-19 and compared them against the values of healthy controls. Serum native thiol (NT), total thiol (TT), disulfide, total antioxidant status, total oxidant status, and ischemia-modified albumin levels were evaluated and compared between groups. RESULTS: A total of 79 children and 74 adults were evaluated in the present study, including 46 children and 40 adults with COVID-19, 33 healthy children, and 34 healthy adults. TT, NT, and disulfide levels were significantly lower in the adult COVID-19 group than in all other groups (p = .001, p = .001, and p = .005, respectively). Additionally, TT and NT levels were significantly lower in both pediatric and adult COVID-19 cases with severe disease course than mild/moderate course. TT and NT levels were identified as predictors for the diagnosis of the adult COVID-19 cases and as independent predictors for disease severity in both children and adults with COVID-19. CONCLUSION: Parameters that reveal the oxidant and antioxidant capacity, including TT and NT, appear to be good candidates for the accurate prediction of the clinical course among patients with COVID-19.
  • |*COVID-19[MESH]
  • |Adult[MESH]
  • |Antioxidants[MESH]
  • |Biomarkers[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Oxidants[MESH]
  • |Oxidative Stress[MESH]
  • |SARS-CoV-2[MESH]
  • |Serum Albumin[MESH]


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