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10.1097/BOR.0000000000000822 http://scihub22266oqcxt.onion/10.1097/BOR.0000000000000822 34264880!8373392!34264880     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34264880&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Rheumatol 2021 ; 33 (5): 419-430 Nephropedia Template TP {{tp|p=34264880|t=2021. Is severe COVID-19 a cytokine storm syndrome: a hyperinflammatory debate |pdf=|usr=}}{{34264880}} gab.com Text Is severe COVID-19 a cytokine storm syndrome: a hyperinflammatory debate JO: Curr Opin Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=34264880 #FOAvip PURPOSE OF REVIEW: The COVID-19 pandemic is a global public health crisis with considerable mortality and morbidity. A role for cytokine storm and therapeutic immunomodulation in a subgroup of patients with severe COVID-19 was proposed early in the pandemic. The concept of cytokine storm in COVID-19 has been criticised, given the lack of clear definition and relatively modest cytokinaemia (which may be necessary for viral clearance) compared with acute respiratory distress syndrome and bacterial sepsis. Here we consider the arguments for and against the concept of cytokine storm in COVID-19. RECENT FINDINGS: Several criteria have been proposed to identify the subgroup of COVID-19 patients exhibiting a cytokine storm. The beneficial effects of corticosteroids and interleukin-6 inhibition suggest that inflammation is a modifiable pathogenic component of severe COVID-19. The presence of genetic polymorphisms and pathogenic auto-autoantibodies in severe COVID-19 also suggests a significant contribution of immune dysregulation to poor outcomes. SUMMARY: Hyperinflammation is a key component of severe COVID-19, residing underneath the cytokine storm umbrella term, associated with poor outcomes. Better understanding of the aetiopathogenesis, with identification of biomarkers to predict treatment responses and prognosis, will hopefully enable a stratified and ultimately precision medicine approach. Twit Text FOAVip Is severe COVID-19 a cytokine storm syndrome: a hyperinflammatory debate ????Curr Opin Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=34264880 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34264880 #FOAvip English Wikipedia <ref>{{Cite pmid|34264880}}</ref> Is severe COVID-19 a cytokine storm syndrome: a hyperinflammatory debate #MMPMID34264880 Mehta P; Fajgenbaum DC Curr Opin Rheumatol 2021[Sep]; 33 (5): 419-430 PMID34264880show ga PURPOSE OF REVIEW: The COVID-19 pandemic is a global public health crisis with considerable mortality and morbidity. A role for cytokine storm and therapeutic immunomodulation in a subgroup of patients with severe COVID-19 was proposed early in the pandemic. The concept of cytokine storm in COVID-19 has been criticised, given the lack of clear definition and relatively modest cytokinaemia (which may be necessary for viral clearance) compared with acute respiratory distress syndrome and bacterial sepsis. Here we consider the arguments for and against the concept of cytokine storm in COVID-19. RECENT FINDINGS: Several criteria have been proposed to identify the subgroup of COVID-19 patients exhibiting a cytokine storm. The beneficial effects of corticosteroids and interleukin-6 inhibition suggest that inflammation is a modifiable pathogenic component of severe COVID-19. The presence of genetic polymorphisms and pathogenic auto-autoantibodies in severe COVID-19 also suggests a significant contribution of immune dysregulation to poor outcomes. SUMMARY: Hyperinflammation is a key component of severe COVID-19, residing underneath the cytokine storm umbrella term, associated with poor outcomes. Better understanding of the aetiopathogenesis, with identification of biomarkers to predict treatment responses and prognosis, will hopefully enable a stratified and ultimately precision medicine approach. |*COVID-19[MESH] |*Cytokine Release Syndrome[MESH] |Cytokines[MESH] |Humans[MESH] |Immunomodulation[MESH] |Pandemics[MESH]Is severe COVID-19 a cytokine storm syndrome: a hyperinflammatory deba(epmc).pdf DeepDyve Pubget Overpricing