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10.1002/jmv.27206

http://scihub22266oqcxt.onion/10.1002/jmv.27206
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34264527!8426941!34264527
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suck abstract from ncbi


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pmid34264527      J+Med+Virol 2021 ; 93 (12): 6794-6797
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  • Cycle threshold values in RT-PCR to determine dynamics of SARS-CoV-2 viral load: An approach to reduce the isolation period for COVID-19 patients #MMPMID34264527
  • Aranha C; Patel V; Bhor V; Gogoi D
  • J Med Virol 2021[Dec]; 93 (12): 6794-6797 PMID34264527show ga
  • Severe acute respiratory syndrome coronavirus (SARS-CoV-2) has affected all inhabited continents, and India is currently experiencing a devastating second wave of coronavirus disease-2019 (COVID-19). Here, we examined the duration of clearance of SARS-CoV-2 in respiratory samples from 207 infected cases by real-time reverse-transcription polymerase chain reaction (RT-PCR). A substantial proportion of COVID-19 positive cases with cycle threshold (Ct) values more than or equal to 31 (45.7%) were subsequently tested negative for SARS-CoV-2 RNA within 7 days of initial detection of the viral load. A total of 60% of all the patients with COVID-19, irrespective of their Ct values, cleared SARS-CoV-2 RNA within 14 days of the initial detection. Longitudinal assessment of RT-PCR test results in individuals requiring 15-30 days to clear SARS-CoV-2 RNA showed a significant reduction of the viral load in samples with high or intermediate viral loads (Ct values /= 31) exhibited a stable viral load. Together, these results suggest that COVID-19 positive cases with Ct values more than or equal to 31 require reduced duration to clear SARS-CoV-2, and thus, a shorter isolation period for this group might be considered to facilitate adequate space in the COVID Care Centres and reduce the burden on healthcare infrastructure.
  • |Adult[MESH]
  • |Aged[MESH]
  • |COVID-19 Testing/methods[MESH]
  • |COVID-19/*virology[MESH]
  • |Diagnostic Tests, Routine/methods[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |India[MESH]
  • |Longitudinal Studies[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |RNA, Viral/genetics[MESH]
  • |Real-Time Polymerase Chain Reaction/methods[MESH]
  • |Reverse Transcriptase Polymerase Chain Reaction/methods[MESH]
  • |SARS-CoV-2/*genetics[MESH]
  • |Sensitivity and Specificity[MESH]
  • |Serologic Tests/methods[MESH]
  • |Viral Load/*genetics[MESH]


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  • suck abstract from ncbi

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