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10.1016/j.celrep.2021.109414 http://scihub22266oqcxt.onion/10.1016/j.celrep.2021.109414 34260965!8238659!34260965     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2021 ; 36 (3): 109414 Nephropedia Template TP {{tp|p=34260965|t=2021. Distinctive features of SARS-CoV-2-specific T cells predict recovery from severe COVID-19 |pdf=|usr=}}{{34260965}} gab.com Text Distinctive features of SARS-CoV-2-specific T cells predict recovery from severe COVID-19 JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=34260965 #FOAvip Although T cells are likely players in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity, little is known about the phenotypic features of SARS-CoV-2-specific T cells associated with recovery from severe coronavirus disease 2019 (COVID-19). We analyze T cells from 34 individuals with COVID-19 with severity ranging from mild (outpatient) to critical, culminating in death. Relative to individuals who succumbed, individuals who recovered from severe COVID-19 harbor elevated and increasing numbers of SARS-CoV-2-specific T cells capable of homeostatic proliferation. In contrast, fatal COVID-19 cases display elevated numbers of SARS-CoV-2-specific regulatory T cells and a time-dependent escalation in activated bystander CXCR4(+) T cells, as assessed by longitudinal sampling. Together with the demonstration of increased proportions of inflammatory CXCR4(+) T cells in the lungs of individuals with severe COVID-19, these results support a model where lung-homing T cells activated through bystander effects contribute to immunopathology, whereas a robust, non-suppressive SARS-CoV-2-specific T cell response limits pathogenesis and promotes recovery from severe COVID-19. Twit Text FOAVip Distinctive features of SARS-CoV-2-specific T cells predict recovery from severe COVID-19 ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=34260965 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34260965 #FOAvip English Wikipedia <ref>{{Cite pmid|34260965}}</ref> Distinctive features of SARS-CoV-2-specific T cells predict recovery from severe COVID-19 #MMPMID34260965 Neidleman J; Luo X; George AF; McGregor M; Yang J; Yun C; Murray V; Gill G; Greene WC; Vasquez J; Lee SA; Ghosn E; Lynch KL; Roan NR Cell Rep 2021[Jul]; 36 (3): 109414 PMID34260965show ga Although T cells are likely players in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity, little is known about the phenotypic features of SARS-CoV-2-specific T cells associated with recovery from severe coronavirus disease 2019 (COVID-19). We analyze T cells from 34 individuals with COVID-19 with severity ranging from mild (outpatient) to critical, culminating in death. Relative to individuals who succumbed, individuals who recovered from severe COVID-19 harbor elevated and increasing numbers of SARS-CoV-2-specific T cells capable of homeostatic proliferation. In contrast, fatal COVID-19 cases display elevated numbers of SARS-CoV-2-specific regulatory T cells and a time-dependent escalation in activated bystander CXCR4(+) T cells, as assessed by longitudinal sampling. Together with the demonstration of increased proportions of inflammatory CXCR4(+) T cells in the lungs of individuals with severe COVID-19, these results support a model where lung-homing T cells activated through bystander effects contribute to immunopathology, whereas a robust, non-suppressive SARS-CoV-2-specific T cell response limits pathogenesis and promotes recovery from severe COVID-19. äDistinctive features of SARS-CoV-2-specific T cells predict recovery f(epmc).pdf DeepDyve Pubget Overpricing