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10.1093/bib/bbab262 http://scihub22266oqcxt.onion/10.1093/bib/bbab262 34260684!8344483!34260684     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Brief+Bioinform 2021 ; 22 (6): ä Nephropedia Template TP {{tp|p=34260684|t=2021. Discovering common pathogenetic processes between COVID-19 and diabetes mellitus by differential gene expression pattern analysis |pdf=|usr=}}{{34260684}} gab.com Text Discovering common pathogenetic processes between COVID-19 and diabetes mellitus by differential gene expression pattern analysis JO: Brief Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=34260684 #FOAvip Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the newly discovered coronavirus, SARS-CoV-2. Increased severity of COVID-19 has been observed in patients with diabetes mellitus (DM). This study aimed to identify common transcriptional signatures, regulators and pathways between COVID-19 and DM. We have integrated human whole-genome transcriptomic datasets from COVID-19 and DM, followed by functional assessment with gene ontology (GO) and pathway analyses. In peripheral blood mononuclear cells (PBMCs), among the upregulated differentially expressed genes (DEGs), 32 were found to be commonly modulated in COVID-19 and type 2 diabetes (T2D), while 10 DEGs were commonly downregulated. As regards type 1 diabetes (T1D), 21 DEGs were commonly upregulated, and 29 DEGs were commonly downregulated in COVID-19 and T1D. Moreover, 35 DEGs were commonly upregulated in SARS-CoV-2 infected pancreas organoids and T2D islets, while 14 were commonly downregulated. Several GO terms were found in common between COVID-19 and DM. Prediction of the putative transcription factors involved in the upregulation of genes in COVID-19 and DM identified RELA to be implicated in both PBMCs and pancreas. Here, for the first time, we have characterized the biological processes and pathways commonly dysregulated in COVID-19 and DM, which could be in the next future used for the design of personalized treatment of COVID-19 patients suffering from DM as comorbidity. Twit Text FOAVip Discovering common pathogenetic processes between COVID-19 and diabetes mellitus by differential gene expression pattern analysis ????Brief Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=34260684 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34260684 #FOAvip English Wikipedia <ref>{{Cite pmid|34260684}}</ref> Discovering common pathogenetic processes between COVID-19 and diabetes mellitus by differential gene expression pattern analysis #MMPMID34260684 Rahman MR; Islam T; Shahjaman M; Islam MR; Lombardo SD; Bramanti P; Ciurleo R; Bramanti A; Tchorbanov A; Fisicaro F; Fagone P; Nicoletti F; Pennisi M Brief Bioinform 2021[Nov]; 22 (6): ä PMID34260684show ga Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the newly discovered coronavirus, SARS-CoV-2. Increased severity of COVID-19 has been observed in patients with diabetes mellitus (DM). This study aimed to identify common transcriptional signatures, regulators and pathways between COVID-19 and DM. We have integrated human whole-genome transcriptomic datasets from COVID-19 and DM, followed by functional assessment with gene ontology (GO) and pathway analyses. In peripheral blood mononuclear cells (PBMCs), among the upregulated differentially expressed genes (DEGs), 32 were found to be commonly modulated in COVID-19 and type 2 diabetes (T2D), while 10 DEGs were commonly downregulated. As regards type 1 diabetes (T1D), 21 DEGs were commonly upregulated, and 29 DEGs were commonly downregulated in COVID-19 and T1D. Moreover, 35 DEGs were commonly upregulated in SARS-CoV-2 infected pancreas organoids and T2D islets, while 14 were commonly downregulated. Several GO terms were found in common between COVID-19 and DM. Prediction of the putative transcription factors involved in the upregulation of genes in COVID-19 and DM identified RELA to be implicated in both PBMCs and pancreas. Here, for the first time, we have characterized the biological processes and pathways commonly dysregulated in COVID-19 and DM, which could be in the next future used for the design of personalized treatment of COVID-19 patients suffering from DM as comorbidity. |COVID-19/*genetics/pathology/virology[MESH] |Computational Biology[MESH] |Diabetes Mellitus/*genetics/pathology[MESH] |Gene Expression Profiling[MESH] |Gene Expression Regulation/genetics[MESH] |Humans[MESH] |Leukocytes, Mononuclear/pathology/virology[MESH] |Protein Interaction Maps/genetics[MESH] |SARS-CoV-2/*genetics/pathogenicity[MESH]Discovering common pathogenetic processes between COVID-19 and diabete(epmc).pdf DeepDyve Pubget Overpricing