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10.7754/Clin.Lab.2020.201050

http://scihub22266oqcxt.onion/10.7754/Clin.Lab.2020.201050
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34258973!ä!34258973

suck abstract from ncbi


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pmid34258973      Clin+Lab 2021 ; 67 (7): ä
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  • Serum 25(OH)D Deficiency and High D-Dimer Levels are Associated with COVID-19 Pneumonia #MMPMID34258973
  • Sunnetcioglu A; Sunnetcioglu M; Gurbuz E; Bedirhanoglu S; Erginoguz A; Celik S
  • Clin Lab 2021[Jul]; 67 (7): ä PMID34258973show ga
  • BACKGROUND: To identify the risk factors for COVID-19 pneumonia and to characterize the epidemiology of the disease. METHODS: This was a prospective study of consecutive patients with SARS-CoV-2 infection and respiratory symptoms, enrolled between April 12 and April 30 of 2020. Pneumonia was diagnosed on the basis of abnormal chest CT findings. At admission, we performed a complete blood count, as well as determining serum levels of CRP, procalcitonin, D-dimer, ferritin, LDH, and 25-hydroxyvitamin D (25[OH]D). Comorbidities, body mass index (BMI), and smoking habits were noted. We also analyzed the risk factors for development of COVID-19 pneumonia. RESULTS: We evaluated 124 patients (79 males) with a mean age of 38 +/- 16.6 years. Fever was observed in 67 patients (54.0%), fatigue, cough, and dyspnea being observed in 94 (75.8%), 86 (69.3%), and 37 (29.8%), respectively. Of the 124 patients, 77 (62.1%) developed pneumonia. Common comorbidities in the patients with pneumonia were hypertension, diabetes, and cardiovascular disease. D-dimer > 0.5 microg/mL (OR = 8.6; 95% CI: 3.32 - 22.26, p < 0.001); 25(OH)D < 20 microg/dL (OR = 6.75; 95% CI: 2.81 - 16.21, p < 0.001); and age > 60 years (OR = 15.66; 95% CI: 2.02 - 121.40, p < 0.001) were variables showing significant correlation with COVID-19 pneumonia. CONCLUSIONS: Serum 25(OH)D deficiency, high D-dimer levels, and advanced age are associated with a greater risk of developing COVID-19 pneumonia.
  • |*COVID-19[MESH]
  • |Adult[MESH]
  • |Fibrin Fibrinogen Degradation Products[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Prospective Studies[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]
  • |Vitamin D/analogs & derivatives[MESH]


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