Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41556-021-00706-w http://scihub22266oqcxt.onion/10.1038/s41556-021-00706-w 34257406!8276549!34257406     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Cell+Biol 2021 ; 23 (8): 846-858 Nephropedia Template TP {{tp|p=34257406|t=2021. ATG9A protects the plasma membrane from programmed and incidental permeabilization |pdf=|usr=}}{{34257406}} gab.com Text ATG9A protects the plasma membrane from programmed and incidental permeabilization JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=34257406 #FOAvip The integral membrane protein ATG9A plays a key role in autophagy. It displays a broad intracellular distribution and is present in numerous compartments, including the plasma membrane (PM). The reasons for the distribution of ATG9A to the PM and its role at the PM are not understood. Here, we show that ATG9A organizes, in concert with IQGAP1, components of the ESCRT system and uncover cooperation between ATG9A, IQGAP1 and ESCRTs in protection from PM damage. ESCRTs and ATG9A phenocopied each other in protection against PM injury. ATG9A knockouts sensitized the PM to permeabilization by a broad spectrum of microbial and endogenous agents, including gasdermin, MLKL and the MLKL-like action of coronavirus ORF3a. Thus, ATG9A engages IQGAP1 and the ESCRT system to maintain PM integrity. Twit Text FOAVip ATG9A protects the plasma membrane from programmed and incidental permeabilization ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=34257406 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34257406 #FOAvip English Wikipedia <ref>{{Cite pmid|34257406}}</ref> ATG9A protects the plasma membrane from programmed and incidental permeabilization #MMPMID34257406 Claude-Taupin A; Jia J; Bhujabal Z; Garfa-Traore M; Kumar S; da Silva GPD; Javed R; Gu Y; Allers L; Peters R; Wang F; da Costa LJ; Pallikkuth S; Lidke KA; Mauthe M; Verlhac P; Uchiyama Y; Salemi M; Phinney B; Tooze SA; Mari MC; Johansen T; Reggiori F; Deretic V Nat Cell Biol 2021[Aug]; 23 (8): 846-858 PMID34257406show ga The integral membrane protein ATG9A plays a key role in autophagy. It displays a broad intracellular distribution and is present in numerous compartments, including the plasma membrane (PM). The reasons for the distribution of ATG9A to the PM and its role at the PM are not understood. Here, we show that ATG9A organizes, in concert with IQGAP1, components of the ESCRT system and uncover cooperation between ATG9A, IQGAP1 and ESCRTs in protection from PM damage. ESCRTs and ATG9A phenocopied each other in protection against PM injury. ATG9A knockouts sensitized the PM to permeabilization by a broad spectrum of microbial and endogenous agents, including gasdermin, MLKL and the MLKL-like action of coronavirus ORF3a. Thus, ATG9A engages IQGAP1 and the ESCRT system to maintain PM integrity. |Autophagosomes/metabolism[MESH] |Autophagy-Related Proteins/genetics/*metabolism[MESH] |Cell Membrane/*metabolism[MESH] |HEK293 Cells[MESH] |HeLa Cells[MESH] |Humans[MESH] |Immunoblotting[MESH] |Immunoprecipitation[MESH] |Membrane Proteins/genetics/*metabolism[MESH] |Microscopy, Confocal[MESH] |Protein Transport/physiology[MESH]ATG9A protects the plasma membrane from programmed and incidental per(epmc).pdf DeepDyve Pubget Overpricing