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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Br+J+Dermatol 2022 ; 186 (1): 142-152 Nephropedia Template TP
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Cutaneous reactions after SARS-CoV-2 vaccination: a cross-sectional Spanish nationwide study of 405 cases #MMPMID34254291
Catala A; Munoz-Santos C; Galvan-Casas C; Roncero Riesco M; Revilla Nebreda D; Sola-Truyols A; Giavedoni P; Llamas-Velasco M; Gonzalez-Cruz C; Cubiro X; Ruiz-Villaverde R; Gomez-Armayones S; Gil Mateo MP; Pesque D; Marcantonio O; Fernandez-Nieto D; Romani J; Iglesias Pena N; Carnero Gonzalez L; Tercedor-Sanchez J; Carretero G; Masat-Tico T; Rodriguez-Jimenez P; Gimenez-Arnau AM; Utrera-Busquets M; Vargas Laguna E; Angulo Menendez AG; San Juan Lasser E; Iglesias-Sancho M; Alonso Naranjo L; Hiltun I; Cutillas Marco E; Polimon Olabarrieta I; Marinero Escobedo S; Garcia-Navarro X; Calderon Gutierrez MJ; Baeza-Hernandez G; Bou Camps L; Toledo-Pastrana T; Guilabert A
Br J Dermatol 2022[Jan]; 186 (1): 142-152 PMID34254291show ga
BACKGROUND: Cutaneous reactions after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are poorly characterized. OBJECTIVE: To describe and classify cutaneous reactions after SARS-CoV-2 vaccination. METHODS: A nationwide Spanish cross-sectional study was conducted. We included patients with cutaneous reactions within 21 days of any dose of the approved vaccines at the time of the study. After a face-to-face visit with a dermatologist, information on cutaneous reactions was collected via an online professional survey and clinical photographs were sent by email. Investigators searched for consensus on clinical patterns and classification. RESULTS: From 16 February to 15 May 2021, we collected 405 reactions after vaccination with the BNT162b2 (Pfizer-BioNTech; 40.2%), mRNA-1273 (Moderna; 36.3%) and AZD1222 (AstraZeneca; 23.5%) vaccines. Mean patient age was 50.7 years and 80.2% were female. Cutaneous reactions were classified as injection site ('COVID arm', 32.1%), urticaria (14.6%), morbilliform (8.9%), papulovesicular (6.4%), pityriasis rosea-like (4.9%) and purpuric (4%) reactions. Varicella zoster and herpes simplex virus reactivations accounted for 13.8% of reactions. The COVID arm was almost exclusive to women (95.4%). The most reported reactions in each vaccine group were COVID arm (mRNA-1273, Moderna, 61.9%), varicella zoster virus reactivation (BNT162b2, Pfizer-BioNTech, 17.2%) and urticaria (AZD1222, AstraZeneca, 21.1%). Most reactions to the mRNA-1273 (Moderna) vaccine were described in women (90.5%). Eighty reactions (21%) were classified as severe/very severe and 81% required treatment. CONCLUSIONS: Cutaneous reactions after SARS-CoV-2 vaccination are heterogeneous. Most are mild-to-moderate and self-limiting, although severe/very severe reactions are reported. Knowledge of these reactions during mass vaccination may help healthcare professionals and reassure patients.
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Br+J+Dermatol 2022 ; 186 (1): 142-152
