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10.1038/s12276-021-00649-0 http://scihub22266oqcxt.onion/10.1038/s12276-021-00649-0 34253862!8273570!34253862     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Exp+Mol+Med 2021 ; 53 (7): 1116-1123 Nephropedia Template TP {{tp|p=34253862|t=2021. Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms |pdf=|usr=}}{{34253862}} gab.com Text Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms JO: Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=34253862 #FOAvip Interleukin-6 (IL-6) plays a crucial role in host defense against infection and tissue injuries and is a bioindicator of multiple distinct types of cytokine storms. In this review, we present the current understanding of the diverse roles of IL-6, its receptors, and its signaling during acute severe systemic inflammation. IL-6 directly affects vascular endothelial cells, which produce several types of cytokines and chemokines and activate the coagulation cascade. Endothelial cell dysregulation, characterized by abnormal coagulation and vascular leakage, is a common complication in cytokine storms. Emerging evidence indicates that a humanized anti-IL-6 receptor antibody, tocilizumab, can effectively block IL-6 signaling and has beneficial effects in rheumatoid arthritis, juvenile systemic idiopathic arthritis, and Castleman's disease. Recent work has also demonstrated the beneficial effect of tocilizumab in chimeric antigen receptor T-cell therapy-induced cytokine storms as well as coronavirus disease 2019 (COVID-19). Here, we highlight the distinct contributions of IL-6 signaling to the pathogenesis of several types of cytokine storms and discuss potential therapeutic strategies for the management of cytokine storms, including those associated with sepsis and COVID-19. Twit Text FOAVip Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms ????Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=34253862 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34253862 #FOAvip English Wikipedia <ref>{{Cite pmid|34253862}}</ref> Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms #MMPMID34253862 Kang S; Kishimoto T Exp Mol Med 2021[Jul]; 53 (7): 1116-1123 PMID34253862show ga Interleukin-6 (IL-6) plays a crucial role in host defense against infection and tissue injuries and is a bioindicator of multiple distinct types of cytokine storms. In this review, we present the current understanding of the diverse roles of IL-6, its receptors, and its signaling during acute severe systemic inflammation. IL-6 directly affects vascular endothelial cells, which produce several types of cytokines and chemokines and activate the coagulation cascade. Endothelial cell dysregulation, characterized by abnormal coagulation and vascular leakage, is a common complication in cytokine storms. Emerging evidence indicates that a humanized anti-IL-6 receptor antibody, tocilizumab, can effectively block IL-6 signaling and has beneficial effects in rheumatoid arthritis, juvenile systemic idiopathic arthritis, and Castleman's disease. Recent work has also demonstrated the beneficial effect of tocilizumab in chimeric antigen receptor T-cell therapy-induced cytokine storms as well as coronavirus disease 2019 (COVID-19). Here, we highlight the distinct contributions of IL-6 signaling to the pathogenesis of several types of cytokine storms and discuss potential therapeutic strategies for the management of cytokine storms, including those associated with sepsis and COVID-19. |Antibodies, Monoclonal, Humanized/immunology/*therapeutic use[MESH] |COVID-19/genetics/immunology/pathology/*prevention & control[MESH] |Cytokine Release Syndrome/genetics/immunology[MESH] |Cytokines/genetics/metabolism[MESH] |Endothelium, Vascular/immunology[MESH] |Humans[MESH] |Interleukin-6/antagonists & inhibitors/*genetics/immunology[MESH] |Receptors, Interleukin-6/antagonists & inhibitors/*genetics/immunology[MESH] |SARS-CoV-2/immunology/pathogenicity[MESH]Interplay between interleukin-6 signaling and the vascular endothelium(epmc).pdf DeepDyve Pubget Overpricing