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10.1093/gerona/glab206 http://scihub22266oqcxt.onion/10.1093/gerona/glab206 34252180!8406858!34252180     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Gerontol+A+Biol+Sci+Med+Sci 2022 ; 77 (1): 33-40 Nephropedia Template TP {{tp|p=34252180|t=2022. Surviving Older Patients Show Preserved Cellular and Humoral Immunological Memory Several Months After SARS-CoV-2 Infection |pdf=|usr=}}{{34252180}} gab.com Text Surviving Older Patients Show Preserved Cellular and Humoral Immunological Memory Several Months After SARS-CoV-2 Infection JO: J Gerontol A Biol Sci Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=34252180 #FOAvip Understanding how older people respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical if we are to confront the coronavirus disease 2019 (COVID-19) pandemic and establish effective vaccination strategies. Immunosenescence reduces the ability to respond to neoantigens and may compromise the life of infected individuals. Here, we analyzed the immunological memory to SARS-CoV-2 in 102 recovered patients aged over 60 years several months after the infection had been resolved. Specific memory T lymphocytes against the virus were measured by interferon-gamma (IFN-gamma) and granzyme B release by ELISpot; memory B-lymphocyte responses were quantified by detection of anti-S IgG1 producer cells by ELISpot and anti-S and anti-N antibodies were determined by enzyme-linked immunosorbent assay (ELISA). Memory T lymphocytes were found in peripheral blood of most of the studied donors, more than 7 months after the infection in some of them. Fewer patients maintained memory B lymphocytes, but antibodies, mainly anti-S, were highly durable and positively correlated with T responses. More robust humoral responses were found in patients who had more severe symptoms and had been admitted to hospital. We concluded that specific immunity against SARS-CoV-2 is effectively preserved regardless of age, despite the great heterogeneity of their immune responses, and that memory T lymphocytes and anti-S IgG might be more durable than memory B cells and anti-N IgG. Twit Text FOAVip Surviving Older Patients Show Preserved Cellular and Humoral Immunological Memory Several Months After SARS-CoV-2 Infection ????J Gerontol A Biol Sci Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=34252180 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34252180 #FOAvip English Wikipedia <ref>{{Cite pmid|34252180}}</ref> Surviving Older Patients Show Preserved Cellular and Humoral Immunological Memory Several Months After SARS-CoV-2 Infection #MMPMID34252180 Garcia-Torre A; Bueno-Garcia E; Lopez-Martinez R; Rioseras B; Moro-Garcia MA; Alonso-Alvarez S; Lluna-Gonzalez A; Sousa-Fernandez A; Fernandez-Gudin M; Campos-Riopedre L; Castro-Del Cueto C; Perez-Fernandez AB; Alonso-Rodriguez A; Menendez-Pena C; Menendez-Pena L; Garcia-Arnaldo N; Feito-Diaz E; Fernandez-Lorences A; Fraile-Manzano A; Fernandez-Iglesias C; Rivera JA; Perez-Fonseca C; Urdiales-Ruano E; Deban-Fernandez M; Mendes-Moreira H; Herrero-Puente P; Alonso-Arias R J Gerontol A Biol Sci Med Sci 2022[Jan]; 77 (1): 33-40 PMID34252180show ga Understanding how older people respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical if we are to confront the coronavirus disease 2019 (COVID-19) pandemic and establish effective vaccination strategies. Immunosenescence reduces the ability to respond to neoantigens and may compromise the life of infected individuals. Here, we analyzed the immunological memory to SARS-CoV-2 in 102 recovered patients aged over 60 years several months after the infection had been resolved. Specific memory T lymphocytes against the virus were measured by interferon-gamma (IFN-gamma) and granzyme B release by ELISpot; memory B-lymphocyte responses were quantified by detection of anti-S IgG1 producer cells by ELISpot and anti-S and anti-N antibodies were determined by enzyme-linked immunosorbent assay (ELISA). Memory T lymphocytes were found in peripheral blood of most of the studied donors, more than 7 months after the infection in some of them. Fewer patients maintained memory B lymphocytes, but antibodies, mainly anti-S, were highly durable and positively correlated with T responses. More robust humoral responses were found in patients who had more severe symptoms and had been admitted to hospital. We concluded that specific immunity against SARS-CoV-2 is effectively preserved regardless of age, despite the great heterogeneity of their immune responses, and that memory T lymphocytes and anti-S IgG might be more durable than memory B cells and anti-N IgG. |*COVID-19[MESH] |*Immunity, Humoral[MESH] |*Immunologic Memory[MESH] |*SARS-CoV-2[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Antibodies, Viral/*immunology[MESH] |Enzyme-Linked Immunospot Assay[MESH] |Female[MESH] |Humans[MESH] |Immunity, Cellular/*physiology[MESH] |Immunoglobulin G[MESH] |Male[MESH] |Memory B Cells[MESH] |Memory T Cells[MESH]Surviving Older Patients Show Preserved Cellular and Humoral Immunolog(epmc).pdf DeepDyve Pubget Overpricing