Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1371/journal.pbio.3001333 http://scihub22266oqcxt.onion/10.1371/journal.pbio.3001333 34252080!8297933!34252080     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Biol 2021 ; 19 (7): e3001333 Nephropedia Template TP {{tp|p=34252080|t=2021. Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies |pdf=|usr=}}{{34252080}} gab.com Text Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies JO: PLoS Biol http://www.kidney.de/pget.php?&tw=1&pmid=34252080 #FOAvip SARS-CoV-2 infections are characterized by viral proliferation and clearance phases and can be followed by low-level persistent viral RNA shedding. The dynamics of viral RNA concentration, particularly in the early stages of infection, can inform clinical measures and interventions such as test-based screening. We used prospective longitudinal quantitative reverse transcription PCR testing to measure the viral RNA trajectories for 68 individuals during the resumption of the 2019-2020 National Basketball Association season. For 46 individuals with acute infections, we inferred the peak viral concentration and the duration of the viral proliferation and clearance phases. According to our mathematical model, we found that viral RNA concentrations peaked an average of 3.3 days (95% credible interval [CI] 2.5, 4.2) after first possible detectability at a cycle threshold value of 22.3 (95% CI 20.5, 23.9). The viral clearance phase lasted longer for symptomatic individuals (10.9 days [95% CI 7.9, 14.4]) than for asymptomatic individuals (7.8 days [95% CI 6.1, 9.7]). A second test within 2 days after an initial positive PCR test substantially improves certainty about a patient's infection stage. The effective sensitivity of a test intended to identify infectious individuals declines substantially with test turnaround time. These findings indicate that SARS-CoV-2 viral concentrations peak rapidly regardless of symptoms. Sequential tests can help reveal a patient's progress through infection stages. Frequent, rapid-turnaround testing is needed to effectively screen individuals before they become infectious. Twit Text FOAVip Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies ????PLoS Biol http://www.kidney.de/pget.php?&tw=1&pmid=34252080 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34252080 #FOAvip English Wikipedia <ref>{{Cite pmid|34252080}}</ref> Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies #MMPMID34252080 Kissler SM; Fauver JR; Mack C; Olesen SW; Tai C; Shiue KY; Kalinich CC; Jednak S; Ott IM; Vogels CBF; Wohlgemuth J; Weisberger J; DiFiori J; Anderson DJ; Mancell J; Ho DD; Grubaugh ND; Grad YH PLoS Biol 2021[Jul]; 19 (7): e3001333 PMID34252080show ga SARS-CoV-2 infections are characterized by viral proliferation and clearance phases and can be followed by low-level persistent viral RNA shedding. The dynamics of viral RNA concentration, particularly in the early stages of infection, can inform clinical measures and interventions such as test-based screening. We used prospective longitudinal quantitative reverse transcription PCR testing to measure the viral RNA trajectories for 68 individuals during the resumption of the 2019-2020 National Basketball Association season. For 46 individuals with acute infections, we inferred the peak viral concentration and the duration of the viral proliferation and clearance phases. According to our mathematical model, we found that viral RNA concentrations peaked an average of 3.3 days (95% credible interval [CI] 2.5, 4.2) after first possible detectability at a cycle threshold value of 22.3 (95% CI 20.5, 23.9). The viral clearance phase lasted longer for symptomatic individuals (10.9 days [95% CI 7.9, 14.4]) than for asymptomatic individuals (7.8 days [95% CI 6.1, 9.7]). A second test within 2 days after an initial positive PCR test substantially improves certainty about a patient's infection stage. The effective sensitivity of a test intended to identify infectious individuals declines substantially with test turnaround time. These findings indicate that SARS-CoV-2 viral concentrations peak rapidly regardless of symptoms. Sequential tests can help reveal a patient's progress through infection stages. Frequent, rapid-turnaround testing is needed to effectively screen individuals before they become infectious. |Adult[MESH] |Athletes[MESH] |Basketball[MESH] |COVID-19 Nucleic Acid Testing/*statistics & numerical data[MESH] |COVID-19/*diagnosis/epidemiology/pathology/virology[MESH] |Convalescence[MESH] |Humans[MESH] |Male[MESH] |Prospective Studies[MESH] |Public Health/methods[MESH] |RNA, Viral/*genetics[MESH] |SARS-CoV-2/*genetics/growth & development[MESH] |Severity of Illness Index[MESH] |United States/epidemiology[MESH] |Virus Replication/*genetics[MESH]Viral dynamics of acute SARS-CoV-2 infection and applications to diagn(epmc).pdf DeepDyve Pubget Overpricing