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10.1080/21505594.2021.1929800

http://scihub22266oqcxt.onion/10.1080/21505594.2021.1929800
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34251989!8276660!34251989
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suck abstract from ncbi


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pmid34251989      Virulence 2021 ; 12 (1): 1771-1794
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  • The journey of SARS-CoV-2 in human hosts: a review of immune responses, immunosuppression, and their consequences #MMPMID34251989
  • Alshammary AF; Al-Sulaiman AM
  • Virulence 2021[Dec]; 12 (1): 1771-1794 PMID34251989show ga
  • Coronavirus disease 2019 (COVID-19) is a highly infectious viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Laboratory findings from a significant number of patients with COVID-19 indicate the occurrence of leukocytopenia, specifically lymphocytopenia. Moreover, infected patients can experience contrasting outcomes depending on lymphocytopenia status. Patients with resolved lymphocytopenia are more likely to recover, whereas critically ill patients with signs of unresolved lymphocytopenia develop severe complications, sometimes culminating in death. Why immunodepression manifests in patients with COVID-19 remains unclear. Therefore, the evaluation of clinical symptoms and laboratory findings from infected patients is critical for understanding the disease course and its consequences. In this review, we take a logical approach to unravel the reasons for immunodepression in patients with COVID-19. Following the footprints of the virus within host tissues, from entry to exit, we extrapolate the mechanisms underlying the phenomenon of immunodepression.
  • |*Immune Tolerance[MESH]
  • |COVID-19/*immunology/pathology[MESH]
  • |Cell Death[MESH]
  • |Cytokine Release Syndrome/immunology/pathology[MESH]
  • |Cytokines/metabolism[MESH]
  • |Humans[MESH]
  • |Immunity[MESH]
  • |Lymphopenia/immunology/pathology[MESH]
  • |SARS-CoV-2/*pathogenicity/physiology[MESH]


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