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10.1111/ijcp.14624

http://scihub22266oqcxt.onion/10.1111/ijcp.14624
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suck abstract from ncbi


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pmid34251730      Int+J+Clin+Pract 2021 ; 75 (11): e14624
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  • Assessment of severity and mortality of COVID-19 with anti-A1 and anti-B IgM isohaemagglutinins, a reflection of the innate immune status #MMPMID34251730
  • Ozcelik F; Tanoglu A; Guven BB; Keskin U; Kaplan M
  • Int J Clin Pract 2021[Nov]; 75 (11): e14624 PMID34251730show ga
  • AIMS: The relationship between the innate immune system that creates the polysaccharide antibody response and COVID-19 is not fully understood. In this study, it was aimed to determine the predictive values of isohaemagglutinins in COVID-19 severity/mortality. METHODS: Approximately 15 440 patients diagnosed with COVID-19 were examined, and a total of 286 patients with anti-B and anti-A1 IgM isohaemagglutinins test results were randomly enrolled in the study. These patients were stratified into two groups according to anti-A1 (n: 138 blood type B or O) and anti-B (n: 148 blood type A) IgM isohaemagglutinins. Anti-A1 or/and anti-B IgM, biochemical parameters, symptoms, chronic diseases, hospitalisation status, intubation status, admission to intensive care unit (ICU) and exitus status were recorded and evaluated for all patients. RESULTS: Anti-A1 IgM and anti-B IgM were significantly lower in ICU patients (7.5 +/- 9.9 vs 18.0 +/- 20.4 and 5.5 +/- 6.3 vs 19.3 +/- 33.6 titres, respectively; P < .01) and in exitus patients (3.8 +/- 3.6 vs 16.7 +/- 18.7 and 3.5 +/- 4.7 vs 16.9 +/- 29.6 titres respectively; P < .01). In the ROC analysis performed to differentiate between exitus and discharge within groups, the sensitivity of anti-B IgM and anti-A1 IgM at cut-off
  • |*COVID-19[MESH]
  • |*Hemagglutinins[MESH]
  • |Humans[MESH]
  • |Immunity, Innate[MESH]
  • |Immunoglobulin M[MESH]
  • |Intensive Care Units[MESH]


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