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10.1021/acsomega.1c01375 http://scihub22266oqcxt.onion/10.1021/acsomega.1c01375 34250342!8247781!34250342     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34250342&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       ACS+Omega 2021 ; 6 (26): 16826-16836 Nephropedia Template TP {{tp|p=34250342|t=2021. SOD1 is a Possible Predictor of COVID-19 Progression as Revealed by Plasma Proteomics |pdf=|usr=}}{{34250342}} gab.com Text SOD1 is a Possible Predictor of COVID-19 Progression as Revealed by Plasma Proteomics JO: ACS Omega http://www.kidney.de/pget.php?&tw=1&pmid=34250342 #FOAvip The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a worldwide health emergency. Patients infected with SARS-CoV-2 present with diverse symptoms related to the severity of the disease. Determining the proteomic changes associated with these diverse symptoms and in different stages of infection is beneficial for clinical diagnosis and management. Here, we performed a tandem mass tag-labeling proteomic study on the plasma of healthy controls and COVID-19 patients, including those with asymptomatic infection (NS), mild syndrome, and severe syndrome in the early phase and the later phase. Although the number of patients included in each group is low, our comparative proteomic analysis revealed that complement and coagulation cascades, cholesterol metabolism, and glycolysis-related proteins were affected after infection with SARS-CoV-2. Compared to healthy controls, ELISA analysis confirmed that SOD1, PRDX2, and LDHA levels were increased in the patients with severe symptoms. Both gene set enrichment analysis and receiver operator characteristic analysis indicated that SOD1 could be a pivotal indicator for the severity of COVID-19. Our results indicated that plasma proteome changes differed based on the symptoms and disease stages and SOD1 could be a predictor protein for indicating COVID-19 progression. These results may also provide a new understanding for COVID-19 diagnosis and treatment. Twit Text FOAVip SOD1 is a Possible Predictor of COVID-19 Progression as Revealed by Plasma Proteomics ????ACS Omega http://www.kidney.de/pget.php?&tw=1&pmid=34250342 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34250342 #FOAvip English Wikipedia <ref>{{Cite pmid|34250342}}</ref> SOD1 is a Possible Predictor of COVID-19 Progression as Revealed by Plasma Proteomics #MMPMID34250342 Xu B; Lei Y; Ren X; Yin F; Wu W; Sun Y; Wang X; Sun Q; Yang X; Wang X; Zhang R; Li Z; Fang S; Liu J ACS Omega 2021[Jul]; 6 (26): 16826-16836 PMID34250342show ga The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a worldwide health emergency. Patients infected with SARS-CoV-2 present with diverse symptoms related to the severity of the disease. Determining the proteomic changes associated with these diverse symptoms and in different stages of infection is beneficial for clinical diagnosis and management. Here, we performed a tandem mass tag-labeling proteomic study on the plasma of healthy controls and COVID-19 patients, including those with asymptomatic infection (NS), mild syndrome, and severe syndrome in the early phase and the later phase. Although the number of patients included in each group is low, our comparative proteomic analysis revealed that complement and coagulation cascades, cholesterol metabolism, and glycolysis-related proteins were affected after infection with SARS-CoV-2. Compared to healthy controls, ELISA analysis confirmed that SOD1, PRDX2, and LDHA levels were increased in the patients with severe symptoms. Both gene set enrichment analysis and receiver operator characteristic analysis indicated that SOD1 could be a pivotal indicator for the severity of COVID-19. Our results indicated that plasma proteome changes differed based on the symptoms and disease stages and SOD1 could be a predictor protein for indicating COVID-19 progression. These results may also provide a new understanding for COVID-19 diagnosis and treatment. ?SOD1 is a Possible Predictor of COVID-19 Progression as Revealed by Pl(epmc).pdf DeepDyve Pubget Overpricing