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10.1016/j.nantod.2021.101243 http://scihub22266oqcxt.onion/10.1016/j.nantod.2021.101243 34249143!8260506!34249143     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nano+Today 2021 ; 40 (ä): 101243 Nephropedia Template TP {{tp|p=34249143|t=2021. TiO(2) supported single Ag atoms nanozyme for elimination of SARS-CoV2 |pdf=|usr=}}{{34249143}} gab.com Text TiO(2) supported single Ag atoms nanozyme for elimination of SARS-CoV2 JO: Nano Today http://www.kidney.de/pget.php?&tw=1&pmid=34249143 #FOAvip The outbreak of SARS-coronavirus 2 (SARS-CoV2) has become a global health emergency. Although enormous efforts have been made, there is still no effective treatment against the new virus. Herein, a TiO(2) supported single-atom nanozyme containing atomically dispersed Ag atoms (Ag-TiO(2) SAN) is designed to serve as a highly efficient antiviral nanomaterial. Compared with traditional nano-TiO(2) and Ag, Ag-TiO(2) SAN exhibits higher adsorption (99.65%) of SARS-CoV2 pseudovirus. This adsorption ability is due to the interaction between SAN and receptor binding domain (RBD) of spike 1 protein of SARS-CoV2. Theoretical calculation and experimental evidences indicate that the Ag atoms of SAN strongly bind to cysteine and asparagine, which are the most abundant amino acids on the surface of spike 1 RBD. After binding to the virus, the SAN/virus complex is typically phagocytosed by macrophages and colocalized with lysosomes. Interestingly, Ag-TiO(2) SAN possesses high peroxidase-like activity responsible for reactive oxygen species production under acid conditions. The highly acidic microenvironment of lysosomes could favor oxygen reduction reaction process to eliminate the virus. With hACE2 transgenic mice, Ag-TiO(2) SAN showed efficient anti-SARS-CoV2 pseudovirus activity. In conclusion, Ag-TiO(2) SAN is a promising nanomaterial to achieve effective antiviral effects for SARS-CoV2. Twit Text FOAVip TiO(2) supported single Ag atoms nanozyme for elimination of SARS-CoV2 ????Nano Today http://www.kidney.de/pget.php?&tw=1&pmid=34249143 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34249143 #FOAvip English Wikipedia <ref>{{Cite pmid|34249143}}</ref> TiO(2) supported single Ag atoms nanozyme for elimination of SARS-CoV2 #MMPMID34249143 Wang D; Zhang B; Ding H; Liu D; Xiang J; Gao XJ; Chen X; Li Z; Yang L; Duan H; Zheng J; Liu Z; Jiang B; Liu Y; Xie N; Zhang H; Yan X; Fan K; Nie G Nano Today 2021[Oct]; 40 (ä): 101243 PMID34249143show ga The outbreak of SARS-coronavirus 2 (SARS-CoV2) has become a global health emergency. Although enormous efforts have been made, there is still no effective treatment against the new virus. Herein, a TiO(2) supported single-atom nanozyme containing atomically dispersed Ag atoms (Ag-TiO(2) SAN) is designed to serve as a highly efficient antiviral nanomaterial. Compared with traditional nano-TiO(2) and Ag, Ag-TiO(2) SAN exhibits higher adsorption (99.65%) of SARS-CoV2 pseudovirus. This adsorption ability is due to the interaction between SAN and receptor binding domain (RBD) of spike 1 protein of SARS-CoV2. Theoretical calculation and experimental evidences indicate that the Ag atoms of SAN strongly bind to cysteine and asparagine, which are the most abundant amino acids on the surface of spike 1 RBD. After binding to the virus, the SAN/virus complex is typically phagocytosed by macrophages and colocalized with lysosomes. Interestingly, Ag-TiO(2) SAN possesses high peroxidase-like activity responsible for reactive oxygen species production under acid conditions. The highly acidic microenvironment of lysosomes could favor oxygen reduction reaction process to eliminate the virus. With hACE2 transgenic mice, Ag-TiO(2) SAN showed efficient anti-SARS-CoV2 pseudovirus activity. In conclusion, Ag-TiO(2) SAN is a promising nanomaterial to achieve effective antiviral effects for SARS-CoV2. äTiO(2) supported single Ag atoms nanozyme for elimination of SARS-CoV2(epmc).pdf DeepDyve Pubget Overpricing