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10.3389/fgene.2021.684152 http://scihub22266oqcxt.onion/10.3389/fgene.2021.684152 34249101!8261158!34249101     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Genet 2021 ; 12 (ä): 684152 Nephropedia Template TP {{tp|p=34249101|t=2021. A Peptide Vaccine Candidate Tailored to Individuals Genetics Mimics the Multi-Targeted T Cell Immunity of COVID-19 Convalescent Subjects |pdf=|usr=}}{{34249101}} gab.com Text A Peptide Vaccine Candidate Tailored to Individuals Genetics Mimics the Multi-Targeted T Cell Immunity of COVID-19 Convalescent Subjects JO: Front Genet http://www.kidney.de/pget.php?&tw=1&pmid=34249101 #FOAvip Long-term immunity to coronaviruses likely stems from T cell activity. We present here a novel approach for the selection of immunoprevalent SARS-CoV-2-derived T cell epitopes using an in silico cohort of HLA-genotyped individuals with different ethnicities. Nine 30-mer peptides derived from the four major structural proteins of SARS-CoV-2 were selected and included in a peptide vaccine candidate to recapitulate the broad virus-specific T cell responses observed in natural infection. PolyPEPI-SCoV-2-specific, polyfunctional CD8(+) and CD4(+) T cells were detected in each of the 17 asymptomatic/mild COVID-19 convalescents' blood against on average seven different vaccine peptides. Furthermore, convalescents' complete HLA-genotype predicted their T cell responses to SARS-CoV-2-derived peptides with 84% accuracy. Computational extrapolation of this relationship to a cohort of 16,000 HLA-genotyped individuals with 16 different ethnicities suggest that PolyPEPI-SCoV-2 vaccination will likely elicit multi-antigenic T cell responses in 98% of individuals, independent of ethnicity. PolyPEPI-SCoV-2 administered with Montanide ISA 51 VG generated robust, Th1-biased CD8(+), and CD4(+) T cell responses against all represented proteins, as well as binding antibodies upon subcutaneous injection into BALB/c and hCD34(+) transgenic mice modeling human immune system. These results have implications for the development of global, highly immunogenic, T cell-focused vaccines against various pathogens and diseases. Twit Text FOAVip A Peptide Vaccine Candidate Tailored to Individuals Genetics Mimics the Multi-Targeted T Cell Immunity of COVID-19 Convalescent Subjects ????Front Genet http://www.kidney.de/pget.php?&tw=1&pmid=34249101 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34249101 #FOAvip English Wikipedia <ref>{{Cite pmid|34249101}}</ref> A Peptide Vaccine Candidate Tailored to Individuals Genetics Mimics the Multi-Targeted T Cell Immunity of COVID-19 Convalescent Subjects #MMPMID34249101 Somogyi E; Csiszovszki Z; Molnar L; Lorincz O; Toth J; Pattijn S; Schockaert J; Mazy A; Miklos I; Pantya K; Pales P; Toke ER Front Genet 2021[]; 12 (ä): 684152 PMID34249101show ga Long-term immunity to coronaviruses likely stems from T cell activity. We present here a novel approach for the selection of immunoprevalent SARS-CoV-2-derived T cell epitopes using an in silico cohort of HLA-genotyped individuals with different ethnicities. Nine 30-mer peptides derived from the four major structural proteins of SARS-CoV-2 were selected and included in a peptide vaccine candidate to recapitulate the broad virus-specific T cell responses observed in natural infection. PolyPEPI-SCoV-2-specific, polyfunctional CD8(+) and CD4(+) T cells were detected in each of the 17 asymptomatic/mild COVID-19 convalescents' blood against on average seven different vaccine peptides. Furthermore, convalescents' complete HLA-genotype predicted their T cell responses to SARS-CoV-2-derived peptides with 84% accuracy. Computational extrapolation of this relationship to a cohort of 16,000 HLA-genotyped individuals with 16 different ethnicities suggest that PolyPEPI-SCoV-2 vaccination will likely elicit multi-antigenic T cell responses in 98% of individuals, independent of ethnicity. PolyPEPI-SCoV-2 administered with Montanide ISA 51 VG generated robust, Th1-biased CD8(+), and CD4(+) T cell responses against all represented proteins, as well as binding antibodies upon subcutaneous injection into BALB/c and hCD34(+) transgenic mice modeling human immune system. These results have implications for the development of global, highly immunogenic, T cell-focused vaccines against various pathogens and diseases. äA Peptide Vaccine Candidate Tailored to Individuals Genetics Mimics t(epmc).pdf DeepDyve Pubget Overpricing