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10.3389/fimmu.2021.694857 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.694857 34248993!8269317!34248993     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 694857 Nephropedia Template TP {{tp|p=34248993|t=2021. Live Virus Neutralisation of the 501Y V1 and 501Y V2 SARS-CoV-2 Variants following INO-4800 Vaccination of Ferrets |pdf=|usr=}}{{34248993}} gab.com Text Live Virus Neutralisation of the 501Y V1 and 501Y V2 SARS-CoV-2 Variants following INO-4800 Vaccination of Ferrets JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34248993 #FOAvip The ongoing COVID-19 pandemic has resulted in significant global morbidity and mortality on a scale similar to the influenza pandemic of 1918. Over the course of the last few months, a number of SARS-CoV-2 variants have been identified against which vaccine-induced immune responses may be less effective. These "variants-of-concern" have garnered significant attention in the media, with discussion around their impact on the future of the pandemic and the ability of leading COVID-19 vaccines to protect against them effectively. To address concerns about emerging SARS-CoV-2 variants affecting vaccine-induced immunity, we investigated the neutralisation of representative 'G614', '501Y.V1' and '501Y.V2' virus isolates using sera from ferrets that had received prime-boost doses of the DNA vaccine, INO-4800. Neutralisation titres against G614 and 501Y.V1 were comparable, but titres against the 501Y.V2 variant were approximately 4-fold lower, similar to results reported with other nucleic acid vaccines and supported by in silico biomolecular modelling. The results confirm that the vaccine-induced neutralising antibodies generated by INO-4800 remain effective against current variants-of-concern, albeit with lower neutralisation titres against 501Y.V2 similar to other leading nucleic acid-based vaccines. Twit Text FOAVip Live Virus Neutralisation of the 501Y V1 and 501Y V2 SARS-CoV-2 Variants following INO-4800 Vaccination of Ferrets ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34248993 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34248993 #FOAvip English Wikipedia <ref>{{Cite pmid|34248993}}</ref> Live Virus Neutralisation of the 501Y V1 and 501Y V2 SARS-CoV-2 Variants following INO-4800 Vaccination of Ferrets #MMPMID34248993 Riddell S; Goldie S; McAuley AJ; Kuiper MJ; Durr PA; Blasdell KR; Tachedjian M; Druce JD; Smith TRF; Broderick KE; Vasan SS Front Immunol 2021[]; 12 (ä): 694857 PMID34248993show ga The ongoing COVID-19 pandemic has resulted in significant global morbidity and mortality on a scale similar to the influenza pandemic of 1918. Over the course of the last few months, a number of SARS-CoV-2 variants have been identified against which vaccine-induced immune responses may be less effective. These "variants-of-concern" have garnered significant attention in the media, with discussion around their impact on the future of the pandemic and the ability of leading COVID-19 vaccines to protect against them effectively. To address concerns about emerging SARS-CoV-2 variants affecting vaccine-induced immunity, we investigated the neutralisation of representative 'G614', '501Y.V1' and '501Y.V2' virus isolates using sera from ferrets that had received prime-boost doses of the DNA vaccine, INO-4800. Neutralisation titres against G614 and 501Y.V1 were comparable, but titres against the 501Y.V2 variant were approximately 4-fold lower, similar to results reported with other nucleic acid vaccines and supported by in silico biomolecular modelling. The results confirm that the vaccine-induced neutralising antibodies generated by INO-4800 remain effective against current variants-of-concern, albeit with lower neutralisation titres against 501Y.V2 similar to other leading nucleic acid-based vaccines. |Animals[MESH] |Antibodies, Neutralizing/metabolism[MESH] |Antibodies, Viral/metabolism[MESH] |Antigenic Variation[MESH] |COVID-19 Vaccines/*immunology[MESH] |COVID-19/*immunology[MESH] |Disease Models, Animal[MESH] |Ferrets[MESH] |Humans[MESH] |Immunization, Secondary[MESH] |Immunogenicity, Vaccine[MESH] |Models, Molecular[MESH] |Mutation/genetics[MESH] |SARS-CoV-2/*physiology[MESH] |Spike Glycoprotein, Coronavirus/genetics[MESH]Live Virus Neutralisation of the 501Y V1 and 501Y V2 SARS-CoV-2 Varian(epmc).pdf DeepDyve Pubget Overpricing