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10.3389/fimmu.2021.594356 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.594356 34248925!8261050!34248925     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 594356 Nephropedia Template TP {{tp|p=34248925|t=2021. Vitamin D and Exercise Are Major Determinants of Natural Killer Cell Activity, Which Is Age- and Gender-Specific |pdf=|usr=}}{{34248925}} gab.com Text Vitamin D and Exercise Are Major Determinants of Natural Killer Cell Activity, Which Is Age- and Gender-Specific JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34248925 #FOAvip BACKGROUND: The coronavirus-19 disease (COVID-19) pandemic reminds us of the importance of immune function, even in immunologically normal individuals. Multiple lifestyle factors are known to influence the immune function. OBJECTIVE: The aim was to investigate the association between NK cell activity (NKA) and multiple factors including vitamin D, physical exercise, age, and gender. METHODS: This was a cross-sectional association study using health check-up and NKA data of 2,095 subjects collected from 2016 to 2018 in a health check-up center in the Republic of Korea. NKA was measured using the interferon-gamma (IFN-gamma) stimulation method. The association of NKA with 25-(OH)-vitamin D (25(OH)D) and other factors was investigated by multiple logistic regression analysis. RESULTS: The average age of subjects was 48.8 +/- 11.6 years (52.9% of subjects were female). Among 2,095 subjects, 1,427 had normal NKA (NKA >/= 500 pg IFN-gamma/mL), while 506 had low NKA (100 </= NKA < 500 pg/mL), and 162 subjects had very low NKA (NKA < 100 pg/mL). Compared to men with low 25(OH)D serum level (< 20 ng/mL), vitamin D replete men (30-39.9 ng/mL) had significantly lower risk of very low NKA (OR: 0.358; 95% CI: 0.138, 0.929; P = 0.035). In women, both low exercise (OR: 0.529; 95% CI: 0.299, 0.939; P = 0.030) and medium to high exercise (OR: 0.522; 95% CI: 0.277, 0.981; P = 0.043) decreased the risk compared to lack of physical exercise. Interestingly, in men and women older than 60 years, physical exercise significantly decreased the risk. Older-age was associated with increased risk of very low NKA in men, but not in women. CONCLUSION: Physical exercise and vitamin D were associated with NKA in a gender- and age-dependent manner. Age was a major risk factor of very low NKA in men but not in women. Twit Text FOAVip Vitamin D and Exercise Are Major Determinants of Natural Killer Cell Activity, Which Is Age- and Gender-Specific ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34248925 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34248925 #FOAvip English Wikipedia <ref>{{Cite pmid|34248925}}</ref> Vitamin D and Exercise Are Major Determinants of Natural Killer Cell Activity, Which Is Age- and Gender-Specific #MMPMID34248925 Oh S; Chun S; Hwang S; Kim J; Cho Y; Lee J; Kwack K; Choi SW Front Immunol 2021[]; 12 (ä): 594356 PMID34248925show ga BACKGROUND: The coronavirus-19 disease (COVID-19) pandemic reminds us of the importance of immune function, even in immunologically normal individuals. Multiple lifestyle factors are known to influence the immune function. OBJECTIVE: The aim was to investigate the association between NK cell activity (NKA) and multiple factors including vitamin D, physical exercise, age, and gender. METHODS: This was a cross-sectional association study using health check-up and NKA data of 2,095 subjects collected from 2016 to 2018 in a health check-up center in the Republic of Korea. NKA was measured using the interferon-gamma (IFN-gamma) stimulation method. The association of NKA with 25-(OH)-vitamin D (25(OH)D) and other factors was investigated by multiple logistic regression analysis. RESULTS: The average age of subjects was 48.8 +/- 11.6 years (52.9% of subjects were female). Among 2,095 subjects, 1,427 had normal NKA (NKA >/= 500 pg IFN-gamma/mL), while 506 had low NKA (100 |*Age Factors[MESH] |*Exercise[MESH] |*Sex Factors[MESH] |Adult[MESH] |COVID-19/epidemiology/*immunology[MESH] |Cells, Cultured[MESH] |Cross-Sectional Studies[MESH] |Female[MESH] |Health Status[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Immunocompetence[MESH] |Interferon-gamma/metabolism[MESH] |Killer Cells, Natural/*immunology[MESH] |Lymphocyte Activation[MESH] |Male[MESH] |Middle Aged[MESH] |Republic of Korea/epidemiology[MESH] |SARS-CoV-2/*physiology[MESH]Vitamin D and Exercise Are Major Determinants of Natural Killer Cell A(epmc).pdf DeepDyve Pubget Overpricing