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10.3389/fendo.2021.658304

http://scihub22266oqcxt.onion/10.3389/fendo.2021.658304
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34248840!8267927!34248840
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suck abstract from ncbi


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pmid34248840      Front+Endocrinol+(Lausanne) 2021 ; 12 (ä): 658304
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  • Type 2 Diabetes Coagulopathy Proteins May Conflict With Biomarkers Reflective of COVID-19 Severity #MMPMID34248840
  • Moin ASM; Al-Qaissi A; Sathyapalan T; Atkin SL; Butler AE
  • Front Endocrinol (Lausanne) 2021[]; 12 (ä): 658304 PMID34248840show ga
  • OBJECTIVE: Detailed proteomic analysis in a cohort of patients with differing severity of COVID-19 disease identified biomarkers within the complement and coagulation cascades as biomarkers for disease severity has been reported; however, it is unclear if these proteins differ sufficiently from other conditions to be considered as biomarkers. METHODS: A prospective, parallel study in T2D (n = 23) and controls (n = 23). A hyperinsulinemic clamp was performed and normoglycemia induced in T2D [4.5 +/- 0.07 mmol/L (81 +/- 1.2 mg/dl)] for 1-h, following which blood glucose was decreased to
  • |Aged[MESH]
  • |Biomarkers/metabolism[MESH]
  • |Blood Coagulation[MESH]
  • |Blood Coagulation Factors/*metabolism[MESH]
  • |COVID-19/*metabolism[MESH]
  • |Case-Control Studies[MESH]
  • |Complement Activation[MESH]
  • |Diabetes Mellitus, Type 2/*metabolism[MESH]
  • |Factor IX/metabolism[MESH]
  • |Female[MESH]
  • |Glucose Clamp Technique[MESH]
  • |Heparin Cofactor II/metabolism[MESH]
  • |Humans[MESH]
  • |Hypoglycemia/*metabolism[MESH]
  • |Kininogens/metabolism[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Peptides/metabolism[MESH]
  • |Platelet Activation[MESH]
  • |Platelet Factor 4/metabolism[MESH]
  • |Prospective Studies[MESH]
  • |Protein C/metabolism[MESH]
  • |Proteomics[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]
  • |Thrombospondin 1/metabolism[MESH]


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