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10.3389/fphys.2021.644149 http://scihub22266oqcxt.onion/10.3389/fphys.2021.644149 34248655!8267530!34248655     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Physiol 2021 ; 12 (ä): 644149 Nephropedia Template TP {{tp|p=34248655|t=2021. Modeling NO Biotransport in Brain Using a Space-Fractional Reaction-Diffusion Equation |pdf=|usr=}}{{34248655}} gab.com Text Modeling NO Biotransport in Brain Using a Space-Fractional Reaction-Diffusion Equation JO: Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=34248655 #FOAvip Nitric oxide (NO) is a small gaseous molecule that is involved in some critical biochemical processes in the body such as the regulation of cerebral blood flow and pressure. Infection and inflammatory processes such as those caused by COVID-19 produce a disequilibrium in the NO bioavailability and/or a delay in the interactions of NO with other molecules contributing to the onset and evolution of cardiocerebrovascular diseases. A link between the SARS-CoV-2 virus and NO is introduced. Recent experimental observations of intracellular transport of metabolites in the brain and the NO trapping inside endothelial microparticles (EMPs) suggest the possibility of anomalous diffusion of NO, which may be enhanced by disease processes. A novel space-fractional reaction-diffusion equation to model NO biotransport in the brain is further proposed. The model incorporates the production of NO by synthesis in neurons and by mechanotransduction in the endothelial cells, and the loss of NO due to its reaction with superoxide and interaction with hemoglobin. The anomalous diffusion is modeled using a generalized Fick's law that involves spatial fractional order derivatives. The predictive ability of the proposed model is investigated through numerical simulations. The implications of the methodology for COVID-19 outlined in the section "Discussion" are purely exploratory. Twit Text FOAVip Modeling NO Biotransport in Brain Using a Space-Fractional Reaction-Diffusion Equation ????Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=34248655 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34248655 #FOAvip English Wikipedia <ref>{{Cite pmid|34248655}}</ref> Modeling NO Biotransport in Brain Using a Space-Fractional Reaction-Diffusion Equation #MMPMID34248655 Tamis A; Drapaca CS Front Physiol 2021[]; 12 (ä): 644149 PMID34248655show ga Nitric oxide (NO) is a small gaseous molecule that is involved in some critical biochemical processes in the body such as the regulation of cerebral blood flow and pressure. Infection and inflammatory processes such as those caused by COVID-19 produce a disequilibrium in the NO bioavailability and/or a delay in the interactions of NO with other molecules contributing to the onset and evolution of cardiocerebrovascular diseases. A link between the SARS-CoV-2 virus and NO is introduced. Recent experimental observations of intracellular transport of metabolites in the brain and the NO trapping inside endothelial microparticles (EMPs) suggest the possibility of anomalous diffusion of NO, which may be enhanced by disease processes. A novel space-fractional reaction-diffusion equation to model NO biotransport in the brain is further proposed. The model incorporates the production of NO by synthesis in neurons and by mechanotransduction in the endothelial cells, and the loss of NO due to its reaction with superoxide and interaction with hemoglobin. The anomalous diffusion is modeled using a generalized Fick's law that involves spatial fractional order derivatives. The predictive ability of the proposed model is investigated through numerical simulations. The implications of the methodology for COVID-19 outlined in the section "Discussion" are purely exploratory. äModeling NO Biotransport in Brain Using a Space-Fractional Reaction-Di(epmc).pdf DeepDyve Pubget Overpricing