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10.2471/BLT.20.255752 http://scihub22266oqcxt.onion/10.2471/BLT.20.255752 34248221!8243027!34248221     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bull+World+Health+Organ 2021 ; 99 (7): 486-495 Nephropedia Template TP {{tp|p=34248221|t=2021. Viral transmission and evolution dynamics of SARS-CoV-2 in shipboard quarantine |pdf=|usr=}}{{34248221}} gab.com Text Viral transmission and evolution dynamics of SARS-CoV-2 in shipboard quarantine JO: Bull World Health Organ http://www.kidney.de/pget.php?&tw=1&pmid=34248221 #FOAvip OBJECTIVE: To examine transmission and evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in shipboard quarantine of the Diamond Princess cruise ship. METHODS: We obtained the full SARS-CoV-2 genome sequences of 28 samples from the Global Initiative on Sharing All Influenza Data database. The samples were collected between 10 and 25 February 2020 and came for individuals who had been tested for SARS-CoV-2 during the quarantine on the cruise ship. These samples were later sequenced in either Japan or the United States of America. We analysed evolution dynamics of SARS-CoV-2 using computational tools of phylogenetics, natural selection pressure and genetic linkage. FINDINGS: The SARS-CoV-2 outbreak in the cruise most likely originated from either a single person infected with a virus variant identical to the WIV04 isolates, or simultaneously with another primary case infected with a virus containing the 11083G > T mutation. We identified a total of 24 new viral mutations across 64.2% (18/28) of samples, and the virus evolved into at least five subgroups. Increased positive selection of SARS-CoV-2 were statistically significant during the quarantine (Tajima's D: -2.03, P < 0.01; Fu and Li's D: -2.66, P < 0.01; and Zeng's E: -2.37, P < 0.01). Linkage disequilibrium analysis confirmed that ribonucleic acid (RNA) recombination with the11083G > T mutation also contributed to the increase of mutations among the viral progeny. CONCLUSION: The findings indicate that the 11083G > T mutation of SARS-CoV-2 spread during shipboard quarantine and arose through de novo RNA recombination under positive selection pressure. Twit Text FOAVip Viral transmission and evolution dynamics of SARS-CoV-2 in shipboard quarantine ????Bull World Health Organ http://www.kidney.de/pget.php?&tw=1&pmid=34248221 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34248221 #FOAvip English Wikipedia <ref>{{Cite pmid|34248221}}</ref> Viral transmission and evolution dynamics of SARS-CoV-2 in shipboard quarantine #MMPMID34248221 Yeh TY; Contreras GP Bull World Health Organ 2021[Jul]; 99 (7): 486-495 PMID34248221show ga OBJECTIVE: To examine transmission and evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in shipboard quarantine of the Diamond Princess cruise ship. METHODS: We obtained the full SARS-CoV-2 genome sequences of 28 samples from the Global Initiative on Sharing All Influenza Data database. The samples were collected between 10 and 25 February 2020 and came for individuals who had been tested for SARS-CoV-2 during the quarantine on the cruise ship. These samples were later sequenced in either Japan or the United States of America. We analysed evolution dynamics of SARS-CoV-2 using computational tools of phylogenetics, natural selection pressure and genetic linkage. FINDINGS: The SARS-CoV-2 outbreak in the cruise most likely originated from either a single person infected with a virus variant identical to the WIV04 isolates, or simultaneously with another primary case infected with a virus containing the 11083G > T mutation. We identified a total of 24 new viral mutations across 64.2% (18/28) of samples, and the virus evolved into at least five subgroups. Increased positive selection of SARS-CoV-2 were statistically significant during the quarantine (Tajima's D: -2.03, P < 0.01; Fu and Li's D: -2.66, P < 0.01; and Zeng's E: -2.37, P < 0.01). Linkage disequilibrium analysis confirmed that ribonucleic acid (RNA) recombination with the11083G > T mutation also contributed to the increase of mutations among the viral progeny. CONCLUSION: The findings indicate that the 11083G > T mutation of SARS-CoV-2 spread during shipboard quarantine and arose through de novo RNA recombination under positive selection pressure. |COVID-19/epidemiology/*genetics/prevention & control/transmission[MESH] |Databases, Nucleic Acid[MESH] |Disease Outbreaks[MESH] |Hong Kong/epidemiology[MESH] |Humans[MESH] |Mutation/genetics[MESH] |Phylogeny[MESH] |Quarantine[MESH] |RNA/genetics[MESH] |SARS-CoV-2/*genetics/isolation & purification[MESH]Viral transmission and evolution dynamics of SARS-CoV-2 in shipboard q(epmc).pdf DeepDyve Pubget Overpricing