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10.1007/s15010-021-01659-w

http://scihub22266oqcxt.onion/10.1007/s15010-021-01659-w
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34247320!8272607!34247320
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suck abstract from ncbi

pmid34247320      Infection 2022 ; 50 (1): 1-9
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  • Laboratory parameters and outcomes in hospitalized adults with COVID-19: a scoping review #MMPMID34247320
  • Zhu A; Zakusilo G; Lee MS; Kim J; Kim H; Ying X; Chen YH; Jedlicka C; Mages K; Choi JJ
  • Infection 2022[Feb]; 50 (1): 1-9 PMID34247320show ga
  • BACKGROUND: Laboratory parameters and the associated clinical outcomes have been an area of focus in COVID-19 research globally. PURPOSE: We performed a scoping review to synthesize laboratory values described in the literature and their associations with mortality and disease severity. METHODS: We identified all primary studies involving laboratory values with clinical outcomes as a primary endpoint by performing data searches in various systematic review databases until 10th August, 2020. Two reviewers independently reviewed all abstracts (13,568 articles) and full text (1126 articles) data. A total of 529 studies involving 165,020 patients from 28 different countries were included. Investigation of the number of studies and patients from a geographical perspective showed that the majority of published literature from January-March 2020 to April-June 2020 was from Asia, though there was a temporal shift in published studies to Europe and the Americas. For each laboratory value, the proportion of studies that noted a statistically significant (p < 0.05) correlation with adverse clinical outcomes (e.g., mortality, disease severity) was tabulated. RESULTS AND CONCLUSION: Among frequently reported laboratory values, blood urea nitrogen was the most often reported predictor of mortality (91%); neutrophil-to-lymphocyte ratio was the most frequent statistically significant laboratory parameter in predicting disease severity (96%). This review highlights the temporal progression of laboratory value frequencies, as well as potentially distinct utilities of different markers for clinical outcomes of COVID-19. Future research pathways include using this collected data for focused quantitative meta-analyses of particular laboratory values correlated with clinical outcomes of mortality and disease severity.
  • |*COVID-19[MESH]
  • |Adult[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Laboratories[MESH]
  • |Lymphocytes[MESH]


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