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10.1016/j.antiviral.2021.105138 http://scihub22266oqcxt.onion/10.1016/j.antiviral.2021.105138 34246735!8264561!34246735     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antiviral+Res 2021 ; 193 (ä): 105138 Nephropedia Template TP {{tp|p=34246735|t=2021. A mouse model of lethal respiratory dysfunction for SARS-CoV-2 infection |pdf=|usr=}}{{34246735}} gab.com Text A mouse model of lethal respiratory dysfunction for SARS-CoV-2 infection JO: Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=34246735 #FOAvip The global spread of SARS-CoV-2 has made millions ill with COVID-19 and even more from the economic fallout of this pandemic. Our quest to test new therapeutics and vaccines require small animal models that replicate disease phenotypes seen in COVID-19 cases. Rodent models of SARS-CoV-2 infection thus far have shown mild to moderate pulmonary disease; mortality, if any, has been associated with prominent signs of central nervous system (CNS) infection and dysfunction. Here we describe the isolation of SARS-CoV-2 variants with propensity for either pulmonary or CNS infection. Using a wild-type SARS-CoV-2 isolated from a COVID-19 patient, we first found that infection was lethal in transgenic mice expressing the human angiotensin I-converting enzyme 2 (hACE2). Fortuitously, full genome sequencing of SARS-CoV-2 from the brain and lung of these animals showed genetic differences. Likewise, SARS-CoV-2 isolates from brains and lungs of these also showed differences in plaque morphology. Inoculation of these brain and lung SARS-CoV-2 isolates into new batch of hACE2 mice intra-nasally resulted in lethal CNS and pulmonary infection, respectively. Collectively, our study suggests that genetic variants of SARS-CoV-2 could be used to replicate specific features of COVID-19 for the testing of potential vaccines or therapeutics. Twit Text FOAVip A mouse model of lethal respiratory dysfunction for SARS-CoV-2 infection ????Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=34246735 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34246735 #FOAvip English Wikipedia <ref>{{Cite pmid|34246735}}</ref> A mouse model of lethal respiratory dysfunction for SARS-CoV-2 infection #MMPMID34246735 Gan ES; Syenina A; Linster M; Ng B; Zhang SL; Watanabe S; Rajarethinam R; Tan HC; Smith GJ; Ooi EE Antiviral Res 2021[Sep]; 193 (ä): 105138 PMID34246735show ga The global spread of SARS-CoV-2 has made millions ill with COVID-19 and even more from the economic fallout of this pandemic. Our quest to test new therapeutics and vaccines require small animal models that replicate disease phenotypes seen in COVID-19 cases. Rodent models of SARS-CoV-2 infection thus far have shown mild to moderate pulmonary disease; mortality, if any, has been associated with prominent signs of central nervous system (CNS) infection and dysfunction. Here we describe the isolation of SARS-CoV-2 variants with propensity for either pulmonary or CNS infection. Using a wild-type SARS-CoV-2 isolated from a COVID-19 patient, we first found that infection was lethal in transgenic mice expressing the human angiotensin I-converting enzyme 2 (hACE2). Fortuitously, full genome sequencing of SARS-CoV-2 from the brain and lung of these animals showed genetic differences. Likewise, SARS-CoV-2 isolates from brains and lungs of these also showed differences in plaque morphology. Inoculation of these brain and lung SARS-CoV-2 isolates into new batch of hACE2 mice intra-nasally resulted in lethal CNS and pulmonary infection, respectively. Collectively, our study suggests that genetic variants of SARS-CoV-2 could be used to replicate specific features of COVID-19 for the testing of potential vaccines or therapeutics. |*Disease Models, Animal[MESH] |Animals[MESH] |Brain/pathology/virology[MESH] |COVID-19/metabolism/mortality/*pathology/virology[MESH] |Female[MESH] |Humans[MESH] |Lung/*pathology/virology[MESH] |Mice[MESH] |Mice, Transgenic[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH]A mouse model of lethal respiratory dysfunction for SARS-CoV-2 infecti(epmc).pdf DeepDyve Pubget Overpricing