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10.1002/jmv.27191 http://scihub22266oqcxt.onion/10.1002/jmv.27191 34245452!8426680!34245452     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2021 ; 93 (12): 6525-6534 Nephropedia Template TP {{tp|p=34245452|t=2021. Updated SARS-CoV-2 single nucleotide variants and mortality association |pdf=|usr=}}{{34245452}} gab.com Text Updated SARS-CoV-2 single nucleotide variants and mortality association JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=34245452 #FOAvip By analyzing newly collected SARS-CoV-2 genomes and comparing them with our previous study about SARS-CoV-2 single nucleotide variants (SNVs) before June 2020, we found that the SNV clustering had changed remarkably since June 2020. Apart from that the group of SNVs became dominant, which is represented by two nonsynonymous mutations A23403G (S:D614G) and C14408T (ORF1ab:P4715L), a few emerging groups of SNVs were recognized with sharply increased monthly incidence ratios of up to 70% in November 2020. Further investigation revealed sets of SNVs specific to patients' ages and/or gender, or strongly associated with mortality. Our logistic regression model explored features contributing to mortality status, including three critical SNVs, G25088T(S:V1176F), T27484C (ORF7a:L31L), and T25A (upstream of ORF1ab), ages above 40 years old, and the male gender. The protein structure analysis indicated that the emerging subgroups of nonsynonymous SNVs and the mortality-related ones were located on the protein surface area. The clashes in protein structure introduced by these mutations might in turn affect the viral pathogenesis through the alteration of protein conformation, leading to a difference in transmission and virulence. Particularly, we explored the fact that nonsynonymous SNVs tended to occur in intrinsic disordered regions of Spike and ORF1ab to significantly increase hydrophobicity, suggesting a potential role in the change of protein folding related to immune evasion. Twit Text FOAVip Updated SARS-CoV-2 single nucleotide variants and mortality association ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=34245452 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34245452 #FOAvip English Wikipedia <ref>{{Cite pmid|34245452}}</ref> Updated SARS-CoV-2 single nucleotide variants and mortality association #MMPMID34245452 Fang S; Liu S; Shen J; Lu AZ; Wang AKY; Zhang Y; Li K; Liu J; Yang L; Hu CD; Wan J J Med Virol 2021[Dec]; 93 (12): 6525-6534 PMID34245452show ga By analyzing newly collected SARS-CoV-2 genomes and comparing them with our previous study about SARS-CoV-2 single nucleotide variants (SNVs) before June 2020, we found that the SNV clustering had changed remarkably since June 2020. Apart from that the group of SNVs became dominant, which is represented by two nonsynonymous mutations A23403G (S:D614G) and C14408T (ORF1ab:P4715L), a few emerging groups of SNVs were recognized with sharply increased monthly incidence ratios of up to 70% in November 2020. Further investigation revealed sets of SNVs specific to patients' ages and/or gender, or strongly associated with mortality. Our logistic regression model explored features contributing to mortality status, including three critical SNVs, G25088T(S:V1176F), T27484C (ORF7a:L31L), and T25A (upstream of ORF1ab), ages above 40 years old, and the male gender. The protein structure analysis indicated that the emerging subgroups of nonsynonymous SNVs and the mortality-related ones were located on the protein surface area. The clashes in protein structure introduced by these mutations might in turn affect the viral pathogenesis through the alteration of protein conformation, leading to a difference in transmission and virulence. Particularly, we explored the fact that nonsynonymous SNVs tended to occur in intrinsic disordered regions of Spike and ORF1ab to significantly increase hydrophobicity, suggesting a potential role in the change of protein folding related to immune evasion. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |COVID-19/*mortality/pathology[MESH] |Female[MESH] |Genome, Viral/*genetics[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Mutation[MESH] |Polymorphism, Single Nucleotide/*genetics[MESH] |Polyproteins/genetics[MESH] |SARS-CoV-2/*genetics/*pathogenicity[MESH] |Spike Glycoprotein, Coronavirus/genetics[MESH] |Viral Proteins/genetics[MESH] |Virulence/genetics[MESH]Updated SARS-CoV-2 single nucleotide variants and mortality associatio(epmc).pdf DeepDyve Pubget Overpricing