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10.1093/cid/ciab626

http://scihub22266oqcxt.onion/10.1093/cid/ciab626
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suck abstract from ncbi


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pmid34245245      Clin+Infect+Dis 2022 ; 74 (7): 1141-1150
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  • Severe Acute Respiratory Syndrome Coronavirus 2 Cumulative Incidence, United States, August 2020-December 2020 #MMPMID34245245
  • Sullivan PS; Siegler AJ; Shioda K; Hall EW; Bradley H; Sanchez T; Luisi N; Valentine-Graves M; Nelson KN; Fahimi M; Kamali A; Sailey C; Lopman BA
  • Clin Infect Dis 2022[Apr]; 74 (7): 1141-1150 PMID34245245show ga
  • BACKGROUND: Reported coronavirus disease 2019 (COVID-19) cases underestimate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. We conducted a national probability survey of US households to estimate cumulative incidence adjusted for antibody waning. METHODS: From August-December 2020 a random sample of US addresses were mailed a survey and self-collected nasal swabs and dried blood spot cards. One adult household member completed the survey and mail specimens for viral detection and total (immunoglobulin [Ig] A, IgM, IgG) nucleocapsid antibody by a commercial, emergency use authorization-approved antigen capture assay. We estimated cumulative incidence of SARS-CoV-2 adjusted for waning antibodies and calculated reported fraction (RF) and infection fatality ratio (IFR). Differences in seropositivity among demographic, geographic, and clinical subgroups were explored. RESULTS: Among 39 500 sampled households, 4654 respondents provided responses. Cumulative incidence adjusted for waning was 11.9% (95% credible interval [CrI], 10.5%-13.5%) as of 30 October 2020. We estimated 30 332 842 (CrI, 26 703 753-34 335 338) total infections in the US adult population by 30 October 2020. RF was 22.3% and IFR was 0.85% among adults. Black non-Hispanics (Prevalence ratio (PR) 2.2) and Hispanics (PR, 3.1) were more likely than White non-Hispanics to be seropositive. CONCLUSIONS: One in 8 US adults had been infected with SARS-CoV-2 by October 2020; however, few had been accounted for in public health reporting. The COVID-19 pandemic is likely substantially underestimated by reported cases. Disparities in COVID-19 by race observed among reported cases cannot be attributed to differential diagnosis or reporting of infections in population subgroups.
  • |*COVID-19/epidemiology[MESH]
  • |*SARS-CoV-2[MESH]
  • |Adult[MESH]
  • |Antibodies, Viral[MESH]
  • |Humans[MESH]
  • |Immunoglobulin A[MESH]
  • |Incidence[MESH]
  • |Pandemics[MESH]


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