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10.1126/science.abg2264 http://scihub22266oqcxt.onion/10.1126/science.abg2264 34244417!7611482!34244417     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2021 ; 373 (6551): 231-236 Nephropedia Template TP {{tp|p=34244417|t=2021. An isoform of Dicer protects mammalian stem cells against multiple RNA viruses |pdf=|usr=}}{{34244417}} gab.com Text An isoform of Dicer protects mammalian stem cells against multiple RNA viruses JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=34244417 #FOAvip In mammals, early resistance to viruses relies on interferons, which protect differentiated cells but not stem cells from viral replication. Many other organisms rely instead on RNA interference (RNAi) mediated by a specialized Dicer protein that cleaves viral double-stranded RNA. Whether RNAi also contributes to mammalian antiviral immunity remains controversial. We identified an isoform of Dicer, named antiviral Dicer (aviD), that protects tissue stem cells from RNA viruses-including Zika virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-by dicing viral double-stranded RNA to orchestrate antiviral RNAi. Our work sheds light on the molecular regulation of antiviral RNAi in mammalian innate immunity, in which different cell-intrinsic antiviral pathways can be tailored to the differentiation status of cells. Twit Text FOAVip An isoform of Dicer protects mammalian stem cells against multiple RNA viruses ????Science http://www.kidney.de/pget.php?&tw=1&pmid=34244417 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34244417 #FOAvip English Wikipedia <ref>{{Cite pmid|34244417}}</ref> An isoform of Dicer protects mammalian stem cells against multiple RNA viruses #MMPMID34244417 Poirier EZ; Buck MD; Chakravarty P; Carvalho J; Frederico B; Cardoso A; Healy L; Ulferts R; Beale R; Reis e Sousa C Science 2021[Jul]; 373 (6551): 231-236 PMID34244417show ga In mammals, early resistance to viruses relies on interferons, which protect differentiated cells but not stem cells from viral replication. Many other organisms rely instead on RNA interference (RNAi) mediated by a specialized Dicer protein that cleaves viral double-stranded RNA. Whether RNAi also contributes to mammalian antiviral immunity remains controversial. We identified an isoform of Dicer, named antiviral Dicer (aviD), that protects tissue stem cells from RNA viruses-including Zika virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-by dicing viral double-stranded RNA to orchestrate antiviral RNAi. Our work sheds light on the molecular regulation of antiviral RNAi in mammalian innate immunity, in which different cell-intrinsic antiviral pathways can be tailored to the differentiation status of cells. |*RNA Interference[MESH] |Alternative Splicing[MESH] |Animals[MESH] |Brain/enzymology/virology[MESH] |Cell Line[MESH] |DEAD-box RNA Helicases/chemistry/*genetics/*metabolism[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Isoenzymes/chemistry/genetics/metabolism[MESH] |Mice[MESH] |Organoids/enzymology/virology[MESH] |RNA Virus Infections/enzymology/immunology/virology[MESH] |RNA Viruses/genetics/immunology/*physiology[MESH] |RNA, Double-Stranded/metabolism[MESH] |RNA, Small Interfering/metabolism[MESH] |RNA, Viral/*metabolism[MESH] |Ribonuclease III/chemistry/*genetics/*metabolism[MESH] |SARS-CoV-2/genetics/immunology/physiology[MESH] |Stem Cells/*enzymology/*virology[MESH] |Virus Replication[MESH] |Zika Virus Infection/enzymology/immunology/virology[MESH]An isoform of Dicer protects mammalian stem cells against multiple RNA(epmc).pdf DeepDyve Pubget Overpricing