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10.1016/j.molimm.2021.06.021 http://scihub22266oqcxt.onion/10.1016/j.molimm.2021.06.021 34242919!8241658!34242919     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34242919&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Immunol 2021 ; 137 (ä): 105-113 Nephropedia Template TP {{tp|p=34242919|t=2021. Untangling COVID-19 and autoimmunity: Identification of plausible targets suggests multi organ involvement |pdf=|usr=}}{{34242919}} gab.com Text Untangling COVID-19 and autoimmunity: Identification of plausible targets suggests multi organ involvement JO: Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34242919 #FOAvip Underlying mechanisms of multi-organ manifestations and exacerbated inflammation in COVID-19 are yet to be delineated. The hypothesis of SARS-CoV-2 triggering autoimmunity is gaining attention and, in the present study, we have identified 28 human proteins harbouring regions homologous to SARS-CoV-2 peptides that could possibly be acting as autoantigens in COVID-19 patients displaying autoimmune conditions. Interestingly, these conserved regions are amongst the experimentally validated B cell epitopes of SARS-CoV-2 proteins. The reported human proteins have demonstrated presence of autoantibodies against them in typical autoimmune conditions which may explain the frequent occurrence of autoimmune conditions following SARS-CoV-2 infection. Moreover, the proposed autoantigens' widespread tissue distribution is suggestive of their involvement in multi-organ manifestations via molecular mimicry. We opine that our report may aid in directing subsequent necessary antigen-specific studies, results of which would be of long-term relevance in management of extrapulmonary symptoms of COVID-19. Twit Text FOAVip Untangling COVID-19 and autoimmunity: Identification of plausible targets suggests multi organ involvement ????Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34242919 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34242919 #FOAvip English Wikipedia <ref>{{Cite pmid|34242919}}</ref> Untangling COVID-19 and autoimmunity: Identification of plausible targets suggests multi organ involvement #MMPMID34242919 Mohkhedkar M; Venigalla SSK; Janakiraman V Mol Immunol 2021[Sep]; 137 (ä): 105-113 PMID34242919show ga Underlying mechanisms of multi-organ manifestations and exacerbated inflammation in COVID-19 are yet to be delineated. The hypothesis of SARS-CoV-2 triggering autoimmunity is gaining attention and, in the present study, we have identified 28 human proteins harbouring regions homologous to SARS-CoV-2 peptides that could possibly be acting as autoantigens in COVID-19 patients displaying autoimmune conditions. Interestingly, these conserved regions are amongst the experimentally validated B cell epitopes of SARS-CoV-2 proteins. The reported human proteins have demonstrated presence of autoantibodies against them in typical autoimmune conditions which may explain the frequent occurrence of autoimmune conditions following SARS-CoV-2 infection. Moreover, the proposed autoantigens' widespread tissue distribution is suggestive of their involvement in multi-organ manifestations via molecular mimicry. We opine that our report may aid in directing subsequent necessary antigen-specific studies, results of which would be of long-term relevance in management of extrapulmonary symptoms of COVID-19. |Autoantibodies/immunology[MESH] |Autoantigens/*immunology[MESH] |Autoimmune Diseases/*complications/immunology/virology[MESH] |Autoimmunity/immunology[MESH] |COVID-19/*etiology/immunology/pathology[MESH] |Epitopes, B-Lymphocyte/*immunology[MESH] |Humans[MESH] |Molecular Mimicry/immunology[MESH]Untangling COVID-19 and autoimmunity: Identification of plausible targ(epmc).pdf DeepDyve Pubget Overpricing