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10.1016/j.chom.2021.05.012 http://scihub22266oqcxt.onion/10.1016/j.chom.2021.05.012 34242582!8173590!34242582     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Host+Microbe 2021 ; 29 (7): 1093-1110 Nephropedia Template TP {{tp|p=34242582|t=2021. HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens |pdf=|usr=}}{{34242582}} gab.com Text HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens JO: Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=34242582 #FOAvip Humanity is currently facing the challenge of two devastating pandemics caused by two very different RNA viruses: HIV-1, which has been with us for decades, and SARS-CoV-2, which has swept the world in the course of a single year. The same evolutionary strategies that drive HIV-1 evolution are at play in SARS-CoV-2. Single nucleotide mutations, multi-base insertions and deletions, recombination, and variation in surface glycans all generate the variability that, guided by natural selection, enables both HIV-1's extraordinary diversity and SARS-CoV-2's slower pace of mutation accumulation. Even though SARS-CoV-2 diversity is more limited, recently emergent SARS-CoV-2 variants carry Spike mutations that have important phenotypic consequences in terms of both antibody resistance and enhanced infectivity. We review and compare how these mutational patterns manifest in these two distinct viruses to provide the variability that fuels their evolution by natural selection. Twit Text FOAVip HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens ????Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=34242582 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34242582 #FOAvip English Wikipedia <ref>{{Cite pmid|34242582}}</ref> HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens #MMPMID34242582 Fischer W; Giorgi EE; Chakraborty S; Nguyen K; Bhattacharya T; Theiler J; Goloboff PA; Yoon H; Abfalterer W; Foley BT; Tegally H; San JE; de Oliveira T; Gnanakaran S; Korber B Cell Host Microbe 2021[Jul]; 29 (7): 1093-1110 PMID34242582show ga Humanity is currently facing the challenge of two devastating pandemics caused by two very different RNA viruses: HIV-1, which has been with us for decades, and SARS-CoV-2, which has swept the world in the course of a single year. The same evolutionary strategies that drive HIV-1 evolution are at play in SARS-CoV-2. Single nucleotide mutations, multi-base insertions and deletions, recombination, and variation in surface glycans all generate the variability that, guided by natural selection, enables both HIV-1's extraordinary diversity and SARS-CoV-2's slower pace of mutation accumulation. Even though SARS-CoV-2 diversity is more limited, recently emergent SARS-CoV-2 variants carry Spike mutations that have important phenotypic consequences in terms of both antibody resistance and enhanced infectivity. We review and compare how these mutational patterns manifest in these two distinct viruses to provide the variability that fuels their evolution by natural selection. |*Pandemics[MESH] |COVID-19/immunology[MESH] |Evolution, Molecular[MESH] |Genome, Viral[MESH] |HIV-1/*genetics[MESH] |Humans[MESH] |Immune Evasion[MESH] |Mutation[MESH] |Receptors, Virus/genetics[MESH] |Recombination, Genetic[MESH] |SARS-CoV-2/*genetics[MESH] |Selection, Genetic[MESH] |Spike Glycoprotein, Coronavirus/chemistry/genetics[MESH]HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathog(epmc).pdf DeepDyve Pubget Overpricing