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10.1371/journal.pone.0254516

http://scihub22266oqcxt.onion/10.1371/journal.pone.0254516
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34242377!8270141!34242377
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suck abstract from ncbi


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pmid34242377      PLoS+One 2021 ; 16 (7): e0254516
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  • Seroprevalence of antibodies against SARS-CoV-2 virus in Northern Serbia (Vojvodina): A four consecutive sentinel population-based survey study #MMPMID34242377
  • Ristic M; Milosavljevic B; Vapa S; Markovic M; Petrovic V
  • PLoS One 2021[]; 16 (7): e0254516 PMID34242377show ga
  • BACKGROUND: Monitoring changes of seroprevalence over time is important at the beginning and during of COVID-19 outbreak to anticipate its dynamics and plan an adequate public health response. METHODS: We conducted a repeated cross-sectional investigation among asymptomatic outpatient subjects and covered 0.1% of total population of Northern Serbia (Autonomous Province of Vojvodina). Each participant was tested for anti-SARS-CoV-2 antibodies using an immunochromatographic qualitative test (point-of-care rapid test). In the last round of survey IgG antibodies targeting the S1 subunit of the spike protein and the nucleocapsid protein of SARS-CoV-2 virus were assessed. RESULTS: During the four rounds of survey (between the end of April and the end of September), anti-SARS-CoV-2 seropositivities based on immunochromatographic test results were 2.60% (95% CI 1.80-3.63), 3.93% (95% CI 2.85-5.28), 6.11% (95% CI 4.72-7.77) and 14.60% (95% 12.51-16.89), respectively. After adjusting with results obtained from the Line immunoassay test, the estimated overall seroprevalence increased to 16.67% (95% CI 14.45-19.08) corresponding to 322,033 infections in total by the end of September 2020 in Vojvodina's population. Throughout the course of the study, for every RT-PCR confirmed case of COVID-19, there were 39-87 additional infections in Vojvodina. No significant difference (p>0.05) in SARS-CoV-2 seropositivity regarding gender and between age subgroups was observed over the course of the survey. CONCLUSIONS: The population prevalence of SARS-CoV-2 antibodies implies much more widespread infection in Vojvodina than indicated by the number of confirmed cases. However, our results suggest that the population of Vojvodina has not reached a desirable level of protection from SARS-CoV-2 virus by the end of September 2020.
  • |*COVID-19 Nucleic Acid Testing[MESH]
  • |*COVID-19/diagnosis/epidemiology/immunology[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Antibodies, Viral/*immunology[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/*immunology[MESH]
  • |Immunoglobulin M/*immunology[MESH]
  • |Infant[MESH]
  • |Infant, Newborn[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Prevalence[MESH]
  • |SARS-CoV-2/genetics/*immunology[MESH]
  • |Serbia/epidemiology[MESH]


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