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10.1016/j.therap.2020.10.004

http://scihub22266oqcxt.onion/10.1016/j.therap.2020.10.004
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34238584!7603945!34238584
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suck abstract from ncbi


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pmid34238584      Therapie 2021 ; 76 (4): 335-345
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  • Harnessing immunotherapy to combat COVID-19: A modern snake oil or silver bullet? #MMPMID34238584
  • Gunjegaonkar SM; Shanmugarajan TS; Arunsundar M; Arjun UVNV; Devi K; Wankhede SB; Ravichandiran V
  • Therapie 2021[Jul]; 76 (4): 335-345 PMID34238584show ga
  • Coronavirus disease 2019 (COVID-19), an infectious disease caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2), has emerged into a global health and economic menace. Amidst the COVID-19 turmoil, recent failures/uncertain outcomes in clinical trials involving the anti-malarial (hydroxychloroquine), anti-viral (remdesivir) or the combination of anti-malarial/antibiotic (hydroxychloroquine/azithromycin) regimens have predisposed the physicians to distrust these "highly-touted" drugs for COVID-19. In this milieu, immunotherapy might be a credible modality to target or modify specific/non-specific immune responses that interfere with the survival of intracellular pathogens. This scientific review throws light on the epidemiology of COVID-19, its pathogenesis and the current clinical scenario of immunotherapeutics including convalescent plasma (CP), type-1 interferons (IFN-I) and human monoclonal antibodies (mAbs) to combat COVID-19. The treatment outcomes underscore that immunotherapy might be a reliable tool to assuage COVID-19-associated immunopathology. However, specific patient pool studies are warranted to ascertain the precise (re)purposing of immunotherapeutics for COVID-19.
  • |*Immunotherapy[MESH]
  • |Antibodies, Monoclonal/therapeutic use[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |COVID-19 Serotherapy[MESH]
  • |COVID-19/*immunology/*therapy/virology[MESH]
  • |Humans[MESH]
  • |Immunization, Passive[MESH]
  • |Interferon Type I/therapeutic use[MESH]
  • |SARS-CoV-2/immunology[MESH]


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