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10.1186/s12879-021-06369-0

http://scihub22266oqcxt.onion/10.1186/s12879-021-06369-0
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34238232!8264491!34238232
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suck abstract from ncbi


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pmid34238232      BMC+Infect+Dis 2021 ; 21 (1): 663
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  • Predictors of mortality in patients with coronavirus disease 2019: a systematic review and meta-analysis #MMPMID34238232
  • Shi C; Wang L; Ye J; Gu Z; Wang S; Xia J; Xie Y; Li Q; Xu R; Lin N
  • BMC Infect Dis 2021[Jul]; 21 (1): 663 PMID34238232show ga
  • BACKGROUND: Coronavirus disease 2019 (COVID-19) is associated with a high mortality rate, especially in patients with severe illness. We conducted a systematic review and meta-analysis to assess the potential predictors of mortality in patients with COVID-19. METHODS: PubMed, EMBASE, the Cochrane Library, and three electronic Chinese databases were searched from December 1, 2019 to April 29, 2020. Eligible studies reporting potential predictors of mortality in patients with COVID-19 were identified. Unadjusted prognostic effect estimates were pooled using the random-effects model if data from at least two studies were available. Adjusted prognostic effect estimates were presented by qualitative analysis. RESULTS: Thirty-six observational studies were identified, of which 27 were included in the meta-analysis. A total of 106 potential risk factors were tested, and the following important predictors were associated with mortality: advanced age, male sex, current smoking status, preexisting comorbidities (especially chronic kidney, respiratory, and cardio-cerebrovascular diseases), symptoms of dyspnea, complications during hospitalization, corticosteroid therapy and a severe condition. Additionally, a series of abnormal laboratory biomarkers of hematologic parameters, hepatorenal function, inflammation, coagulation, and cardiovascular injury were also associated with fatal outcome. CONCLUSION: We identified predictors of mortality in patients with COVID-19. These findings could help healthcare providers take appropriate measures and improve clinical outcomes in such patients.
  • |Adrenal Cortex Hormones/administration & dosage[MESH]
  • |Age Distribution[MESH]
  • |COVID-19/*diagnosis/*mortality[MESH]
  • |Cardiovascular Diseases/epidemiology[MESH]
  • |Comorbidity[MESH]
  • |Databases, Factual[MESH]
  • |Dyspnea/epidemiology[MESH]
  • |Female[MESH]
  • |Hospitalization/statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Inflammation/epidemiology[MESH]
  • |Kidney/physiopathology[MESH]
  • |Liver/physiopathology[MESH]
  • |Male[MESH]
  • |Observational Studies as Topic[MESH]
  • |Prognosis[MESH]
  • |Risk Factors[MESH]
  • |Sex Distribution[MESH]


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