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10.1016/j.chom.2021.05.010

http://scihub22266oqcxt.onion/10.1016/j.chom.2021.05.010
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34237248!8139264!34237248
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suck abstract from ncbi


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pmid34237248      Cell+Host+Microbe 2021 ; 29 (7): 1076-1092
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  • SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19 #MMPMID34237248
  • Grifoni A; Sidney J; Vita R; Peters B; Crotty S; Weiskopf D; Sette A
  • Cell Host Microbe 2021[Jul]; 29 (7): 1076-1092 PMID34237248show ga
  • Over the past year, numerous studies in the peer reviewed and preprint literature have reported on the virological, epidemiological and clinical characteristics of the coronavirus, SARS-CoV-2. To date, 25 studies have investigated and identified SARS-CoV-2-derived T cell epitopes in humans. Here, we review these recent studies, how they were performed, and their findings. We review how epitopes identified throughout the SARS-CoV2 proteome reveal significant correlation between number of epitopes defined and size of the antigen provenance. We also report additional analysis of SARS-CoV-2 human CD4 and CD8 T cell epitope data compiled from these studies, identifying 1,400 different reported SARS-CoV-2 epitopes and revealing discrete immunodominant regions of the virus and epitopes that are more prevalently recognized. This remarkable breadth of epitope repertoire has implications for vaccine design, cross-reactivity, and immune escape by SARS-CoV-2 variants.
  • |*Adaptive Immunity[MESH]
  • |Antigens, Viral[MESH]
  • |CD4-Positive T-Lymphocytes/immunology[MESH]
  • |CD8-Positive T-Lymphocytes/immunology[MESH]
  • |COVID-19/*immunology[MESH]
  • |Cross Reactions[MESH]
  • |Epitopes[MESH]
  • |Epitopes, T-Lymphocyte/*immunology[MESH]
  • |Humans[MESH]
  • |Immunodominant Epitopes[MESH]


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