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10.1016/j.intimp.2021.107598

http://scihub22266oqcxt.onion/10.1016/j.intimp.2021.107598
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34233864!8135227!34233864
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suck abstract from ncbi


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pmid34233864      Int+Immunopharmacol 2021 ; 101 (Pt B): 107598
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  • MCP-1: Function, regulation, and involvement in disease #MMPMID34233864
  • Singh S; Anshita D; Ravichandiran V
  • Int Immunopharmacol 2021[Dec]; 101 (Pt B): 107598 PMID34233864show ga
  • MCP-1 (Monocyte chemoattractant protein-1), also known as Chemokine (CC-motif) ligand 2 (CCL2), is from family of CC chemokines. It has a vital role in the process of inflammation, where it attracts or enhances the expression of other inflammatory factors/cells. It leads to the advancement of many disorders by this main mechanism of migration and infiltration of inflammatory cells like monocytes/macrophages and other cytokines at the site of inflammation. MCP-1 has been inculpated in the pathogenesis of numerous disease conditions either directly or indirectly like novel corona virus, cancers, neuroinflammatory diseases, rheumatoid arthritis, cardiovascular diseases. The elevated MCP-1 level has been observed in COVID-19 patients and proven to be a biomarker associated with the extremity of disease along with IP-10. This review will focus on involvement and role of MCP-1 in various pathological conditions.
  • |Animals[MESH]
  • |Biomarkers[MESH]
  • |Chemokine CCL2/genetics/*immunology/physiology[MESH]
  • |Chemotaxis[MESH]
  • |Disease[MESH]
  • |Humans[MESH]
  • |Monocytes/physiology[MESH]


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